department of pharmacology

Janos Kerner, Ph.D.

Janos Kerner

Associate Professor

Phone: (216) 368-5358
Fax: 216-368-1300

Janos Kerner graduated from Humboldt University in Berlin (Germany) where he received his M.S. in Biology/Plant Biochemistry. He accepted a teaching/research position in the Department of Biochemistry at Medical University of Pecs (Hungary) where he received his Ph.D. in biochemistry. He held a faculty position at Medical University at Pecs until 1994. During his faculty appointment in the Department of Biochemistry at the Medical University of Pecs, he worked for several years as a visiting faculty in the Department of Biochemistry at Michigan State University. He joined the faculty in the Department of Nutrition at CWRU in 1995.



The elucidation of the functions of carnitine acyltransferases and acylcarnitines in intermediary metabolism and the investigation of the regulation of mitochondrial malonyl-CoA sensitive carnitine palmitoyltransferase (CPT-I).

My past research focused in method and assay developments for identification and quantitation of individual acylcarnitines. Since then I have shown that carnitine is involved in specific detoxification reactions, and in modulating the acyl-CoA/CoASH ratio in cellular compartments.

My current research is in the area of mitochondrial fatty acid oxidation with special emphasis on the malonyl-CoA sensitive carnitine palmitoyltransferase. CPT-I exists in two isoforms, the liver and muscle specific isoform, and catalyzes the rate controlling step of mitochondrial fatty acid oxidation.

Consequently, its regulation (allostericaly by malonyl-CoA and covalently by phosphorylation) is central to several pathological conditions. Our aim is to elucidate how the two isoforms are regulated in vivo under physiological and pathological conditions using a multifaceted approach which involves enzymological and immunological methods as well as proteomics.