PHARMACOLOGY

McBee JK, Van Hooser JP, Jang G-F, Palczewski K : Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. J Biol Chem 2001;276:48483-48493

Sokal I, Li N, Klug CS, Filipek S, Hubbell WL, Baehr W, Palczewski K : Calcium-sensitive regions of GCAP1 as observed by chemical modificatons, fluorescence, and EPR spectroscopies. J Biol Chem 2001;276:43361-43373

Li N, Sokal I, Bronson JD, Palczewski K , Baehr W: Identification of functional regions of guanylate cyclase-activating protein 1 (GCAP1) using GCAP1/GCIP chimeras. Biol Chem 2001;382:1179-88.

Jang GF, Van Hooser JP, Kuksa V, McBee JK, He Y-G, Janssen JJ, Driessen CA, Palczewski K : Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene: a model for the human hereditary disease fundus albipunctatus. J Biol Chem 2001;276:32456-65.

Mendez A, Burns ME, Sokal I, Dizhoor AM, Baehr W, Palczewski K , Baylor DA, Chen J: Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci USA 2001;98:9948-53.

Jang G-F, Kuksa V, Filipek S, Bartl F, Ritter E, Gelb MH, Hofmann KP, Palczewski K : Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein. J Biol Chem 2001;276:26148-53.

Teller DC, Okada T, Behnke CA, Palczewski K , Stenkamp RE: Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GCPRs). Biochemistry 2001;40:7761-72.

Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K : Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. J Biol Chem 2001;276:22287-95.

Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro PA, Palczewski K , Zack DJ: Cloning and characterization of a human ß,ß-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics 2001;72:193-202.

Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K , Smith I, Komesaroff P, Krozowski Z: Pan1ß (17bHSD11)-enzymatic activity and distribution in the lung. Molec Cell Endocrinol 2001;171:111-17.

Okada T, Palczewski K : Crystal structure of rhodopsin: implications for vision and beyond. Curr Opin Struct Biol 2001;11:420–426.

Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K : Gene transfer mediated by recombinant baculovirus into mouse eye. Invest Ophthalmol Vis Sci 2001;42:3294-300.

Ballesteros J, Palczewski K : G protein-coupled receptor drug discovery: Implications from the crystal structure of rhodopsin. Current Opinion in Drug Discovery & Development 2001;4(5):561-574.

McBee JK, Palczewski K , Baehr W, Pepperberg DR: Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retina Eye Res. 2001;20(4):469-529.