Krzysztof Palczewski, Ph.D.
1995-1999 Publications
Palczewski K , Verlinde CL, Haeseleer F: Molecular mechanism of visual transduction. Novartis Found Symp. 1999;224:191-204; discussion 204-7.
Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C-KJ, Palczewski K , Wensel TG, Baehr W: Structure, alternative splicing, and expression of the human RGS9 gene. Gene 1999;240:23-34.
Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K : Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry 1999;38:13542-50.
Palczewski K , Van Hooser JP, Garwin GG, Chen J, Liou GI, Saari JC: Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry 1999;38:12012-19.
Zhao X, Yokoyama K, Whitten ME, Huang J, Gelb MH, Palczewski K : A novel form of rhodopsin kinase from chicken retina and pineal gland. FEBS Letters 1999;454:115-21.
Sokal I, Otto-Bruc AE, Surgucheva I, Verlinde CL, Wang CK, Baehr W, Palczewski K : Conformational changes in guanylyl cyclase-activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. J Biol Chem 1999;274:19829-37.
Ames JB, Dizhoor AM, Ikura M, Palczewski K , Stryer L: Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases. J Biol Chem 1999; 274:19329-37.
Mukherjee S, Palczewski K , Gurevich VV, Hunzicker-Dunn M: b-Arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor. J Biol Chem 1999;274:12984-9.
Stecher H, Gelb MH, Saari JC, Palczewski K : Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein (CRALBP). J Biol Chem 1999;274:8577-85.
Wolbring G, Baehr W, Palczewski K , Schnetkamp PPM: Light inhibition of bovine retinal rod guanylyl cyclase mediated by bg-transducin. Biochemistry 1999;38:2611-16.
Haeseleer F, Sokal I, Li N, Pettanati M, Rao N, Bronson D, Wechter R, Baehr W, Palczewski K : Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. J Biol Chem 1999;274:6526-35.
Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K : Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase1. Biochemistry 1999;38:1387-93.
Mukherjee S, Palczewski K , Gurevich V, Benovic JL, Banga JP, Hunzicker-Dunn M: A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Proc Natl Acad Sci USA 1999;96:493-8.
Ohguro H, Yoshida N, Crabb JW, Palczewski K , Tsuda M: Identification of a single phosphorylation site within octopus rhodopsin. Photochem Photobiol 1998;68:824-8.
Otto-Bruc AE, Fariss RN, Van Hooser JP, Palczewski K : Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by a-toxin. Proc Natl Acad Sci USA 1998;95:15014-19.
Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K : Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. J Biol Chem 1998;273:21790-9.
Sokal I, Li N, Surgucheva I, Warren MJ, Payne AM, Bhattacharya SS, Baehr W, Palczewski K : GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. Molecular Cell 1998;2(1):129-33.
Cowan CW, Fariss RN, Sokal I, Palczewski K , Wensel TG: High expression levels in cones of RGS9, the predominant GTPase-accelerating protein of rods. Proc Natl Acad Sci USA 1998;95: 5351-6.
Moon C, Jaberi P, Otto-Bruc A, Baehr W, Palczewski K , Ronnett GV: Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J Neurosci 1998;18: 3195-3205.
Li N, Fariss RN, Zhang K, Otto-Bruc A, Haeseleer F, Bronson D, Qin N, Yamazaki A, Subbaraya I, Milam AH, Palczewski K , Baehr W: Guanylate-cyclase-inhibitory protein is a frog retinal Ca2+-binding protein related to mammalian guanylate-cyclase-activating proteins. Eur J Biochem 1998;252:591-9.
Saari JC, Garwin GG, Van Hooser JP, Palczewski K : Reduction of all-trans-retinal limits regeneration of visual pigment in mice. Vision Research 1998;38:1325-33.
Zhao X, Huang J, Khani SC, Palczewski K : Molecular forms of human rhodopsin kinase (GRK1). J Biol Chem 1998;273:5124-31.
Rudnicka-Nawrot M, Surgucheva I, Hulmes JD, Haeseleer F, Sokal I, Crabb JW, Baehr W, Palczewski K : Changes in biological activity and folding of guanylate cyclase-activating protein 1 as a function of calcium. Biochemistry 1998;37:248-57.
Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K , Baehr W: A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Nat'l Acad Sci USA 1998;95:1271-6.
Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K : Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Nat'l Acad Sci USA 1998;95:328-33.
Johnson WC Jr, Palczewski K , Gorczyca WA, Riazance-Lawrence JH, Witkowska D, Polans AS: Calcium binding to recoverin: implications for secondary structure and membrane association. Biochim Biophys Acta 1997;1342:164-74.
Pulvermüller A, Maretzki D, Rudnicka-Nawrot M, Smith WC, Palczewski K , Hofmann KP: Functional differences in the interaction of arrestin and its splice variant, p44, with rhodopsin. Biochemistry 1997;36:9253-60.
Otto-Bruc A, Fariss RN, Haeseleer F, Huang J, Buczylko J, Surgucheva I, Baehr W, Milam AH, Palczewski K : Localization of guanylate cyclase-activating protein 2 in mammalian retinas. Proc Nat'l Acad Sci USA 1997;94:4727-32.
Otto-Bruc A, Buczylko J, Surgucheva I, Subbaraya I, Rudnicka-Nawrot M, Crabb JW, Arendt A, Hargrave PA, Baehr W, Palczewski K : Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein. Biochemistry 1997; 36:4295-4302.
Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, Palczewski K , Baehr W: The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). Genomics 1997;39:312-22.
Zhao X-Y, Haeseleer F, Fariss RN, Huang J, Milam AH, Palczewski K : Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Visual Neurosci 1997;14:225-32.
Palczewski K , Smith WC: Splice variants of arrestins. Exp Eye Res 1996;63:599-602.
Saari Jc,Buczylko J, Crouch RK, Palczewski K : Mechanisms of opsin activation. J Biol Chem 1996;271:20621-31.
Duda T, Goraczniak R, Surgucheva I, Rudnicka-Nawrot M, Gorczyca WA, Palczewski K , Sitaramayya A, Baehr W, Sharma RK: Calcium modulation of bovine photoreceptor guanylate cyclase. Biochemistry 1996;35:8478-82.
Langlois G, Chen C-K, Palczewski K , Hurley JB, Vuong TM: Responses of the phototransduction cascade to dim light. Proc Natl Acad Sci USA 1996;93:4677-82.
Semple-Rowland SL, Gorczyca WA, Buczylko J, Helekar BS, Ruiz CC, Subbaraya I, Palczewski K , Baehr W: Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina. FEBS Letters 1996;385:47-52.
Jäger S, Palczewski K , Hofmann KP: Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin. Biochemistry 1996;35: 2901?8.
Ohguro H, Rudnicka-Nawrot M, Buczylko J, Zhao X, Taylor JA, Walsh KA, Palczewski K : Structural and enzymatic aspects of rhodopsin phosphorylation. J Biol Chem 1996;271:5215-24.
Baehr W, Palczewski K : "Two distinct guanylate cyclase-activating proteins in the mammalian retina." Proceedings of The Second Great Basin Visual Science Symposium, "Physiological and Molecular Mechanisms of Retinal Function," 8/25/95, Salt Lake City, Utah, vol. II, pp. 22-7.
Smith WC, Adamus G, van der Wel H, Timmers A, Palczewski K , Ulshafer RJ, Hargrave PA, McDowell JH: Alligator rhodopsin: Sequence and biochemical properties. Exp Eye Res 1995;61: 569-78.
Gorczyca WA, Polans AS, Surgucheva IG, Subbaraya I, Baehr W, Palczewski K : Guanylyl cyclase-activating protein (GCAP): A calcium-sensitive regulator of phototransduction. J Biol Chem 1995; 270:22029-36.
Zhao X, Palczewski K , Ohguro H: Mechanism of rhodopsin phosphorylation. Biophysical Chem 1995;56:183-8.
Kozak CA, Danciger M, Bowes C, Adamson MC, Palczewski K , Polans AS, Farber DB: Localization of three genes expressed in retina on mouse chromosome 11. Mamm Genome 1995;6:142-4.
Ohguro H, Palczewski K : Separation of phospho- and nonphosphopeptides using reverse-phase column chromatography. FEBS Letters 1995;368:452-4.
Palczewski K , Ohguro H, Premont RT, Inglese J: Rhodopsin kinase autophosphorylation: Characterization of site-specific mutations. J Biol Chem 1995;270:15294-8.
Ohguro H, Van Hooser JP, Milam AH, Palczewski K : Rhodopsin phosphorylation and dephosphorylation in vivo. J Biol Chem 1995;270:14259-62.