The research in the Maguire lab is focused primarily on the structure and function
of Mg2+ channels and transporters in bacterial metabolism and pathogenesis
using primarily Salmonella enterica serovar Typhimurium (S. Typhimurium)
as a model system.
Structure of CorA, ZntB and MgtE including x-ray crystallographic analysis of the
full length proteins and their soluble domains. (In collaboration with Dr. Chris
Dealwis and Dr. Osamu Nureki)
Regulation of CorA and ZntB ion flux by putative cytoplasmic binding proteins.
Development of the zebrafish as a model of Mg<sup>2+</sup> homeostasis.
(In collaboration with Dr. Johannes von Lintig)
Key Recent Publications:
Papp, K. and M.E. Maguire (2004) “The CorA Mg2+ Transporter Does
Not Transport Fe2+,” J. Bacteriology 186:7653-7658.
Zaharik, M.L. V. L. Cullen, A. M. Fung, S. J. Libby, S. Kujat-Choy, B. Coburn, D.
G. Kehres, M. E. Maguire, F. C. Fang, and B. B. Finlay (2004) The Salmonella enterica
serovar Typhimurium divalent cation transport systems MntH and SitABCD are essential
for virulence in an Nramp1G169 murine typhoid model, Infection and Immunity
Lunin, V.L., E. Dobrovetsky, G. Khutoreskaya, R. Zhang, A. Joachimiak, A. Bochkarev,
M.E. Maguire, A.M. Edwards, C.M. Koth (2006) “Crystal Structure of the CorA
Mg2+ Transporter from Thermotoga maritima,” Nature
Papp-Wallace, K. and M.E. Maguire (2006) “Manganese Transport and the Role
of Manganese in Virulence,” Ann. Rev. Microbiol.60:187-209
Maguire, M.E. (2006) “Magnesium Transporters: Properties, Regulation and Structure”,
Frontiers in Bioscience, 11:3149-3163.
Günzel, D., D.G. Kehres, L. Kucharski, M.F. Romero and M.E. Maguire (2006) “The
MgtC Virulence Factor of Salmonella enterica serovar Typhimurium Activates
Na+,K+-ATPase”, J. Bacteriology 188:5586-5594.
Maguire, M.E. (2006) “The Structure of CorA:A Mg2+-Selective Channel,”
Curr. Opin. Structural Biol 16:432-438.
Papp-Wallace, K.M. and M.E. Maguire (2008) “Magnesium transport and Magnesium
Homeostasis,” in EcoSal: online version of “Escherichia coli
and Salmonella: Cellular and Molecular Biology,” ASM Press, Washington,
Papp-Wallace, K.M., M. Nartea, D.G. Kehres, S. Porwollik, M. McClelland,
S.J. Libby, F.C. Fang, and M.E. Maguire (2008) “The CorA Mg2+ channel
is required for the virulence of Salmonella enterica serovar Typhimurium”,
J. Bacteriology, 190:6517-6523.
Papp-Wallace, K.M. and M.E. Maguire (2008) “Regulation of the CorA Mg2+
channel affects the virulence of Salmonella enterica serovar Typhimurium,”
J. Bacteriology, 190:6509-6516.
Moomaw, A.S. and M.E. Maguiire (2008) “The
Unique Nature of Mg2+ Channels,” Physiology, 23:275-285.