department of pharmacology

Krzysztof Palczewski, Ph.D.

2003 Publications

Sokal I, Alekseev A, Palczewski K.
Photoreceptor guanylate cyclase variants: cGMP production under control.
Acta Biochim Pol. 2003;50(4):1075-95.

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Filipek S, Stenkamp RE, Teller DC, Palczewski K G Protein-Coupled Receptor Rhodopsin: A prospectus. Annu Rev Physiol 2003;65:851-79. Supplementary Materials
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Heck M, Schadel S, Maretzki D, Bartl F, Ritter E, Palczewski K, Hofmann KP: Signaling states of rhodopsin: formation of the storage form, metarhodopsin III, from active metarhodopsin II. J Biol Chem 2003;278:3162-3169.
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Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K: Rhodopsin dimers in native disc membranes. Nature 2003;421:127-128.
Commentary: Fotaidas et al. Is rhodopsin dimeric in native retinal rods? Nature 2003; 426: 30-31.
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Filipek S, Teller DC, Palczewski K, Stenkamp R: The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. Annu Rev Biophys Biomol Struct 2003;32:375-97. Figures
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Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP: Role of the Conserved NPxxY(x)5,6F Motif in the Rhodopsin Ground State and During Activation. Proc Natl Acad Sci USA 2033;100:2290-2295.
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Sokal I, Hu G, Liang Y, Mao M, Wensel TG, Palczewski K: Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. J Biol Chem 2003;278:8316-8325.
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Mirzadegan R, Benko G, Filipek S, Palczewski K: Sequence analyses of G-protein-coupled receptors: Similarities to rhodopsin. Biochemistry 2003;42:2759-2767. Supporting information

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Maeda T, Van Hooser J, Dreissen C, Filipek S, Janssen J, Palczewski K: Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. J. Neurochem 2003;85:944-956.
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Noorwez S, Kuska V, Imanishi Y, Zhu L, Filipek, S, Palczewski K, Kaushal S: Pharmacological Chaperone-mediated in Vivo Folding and Stabilization of the P23H-opsin Mutant Associated with Autosomal Dominant Retinitis Pigmentosa J Biol Chem 2003;278:14442-14450.
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Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A: Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes. J Biol Chem 2003; 278(24):21655-62.

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Maeda T, Imanishi Y, Palczewski K: Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res 2003; 22:417-34.

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Schadel SA, Heck M, Maretzki D, Filipek S, Teller DC, Palczewski K, Hofmann KP: Ligand channeling within a G-protein-coupled receptor: The entry and exit of retinals in native opsin. J Biol Chem 2003; 278(27):24896-24903.

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Marmor MF, Haeseleer F, Palczewski K: Albipunctate retinopathy with core dysfunction and no abnormality in the RDH5 or RLBP1 genes. Retina 2003; 23(4):543-546.

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Ridge KD, Abdulaev NG, Sousa M, Palczewski K: Phototransduction: crystal clear. Trends in Biochem. Sci. 2003; 28(9):479-486.

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Driessen C, Winkens H, Haeseleer F, Palczewski K, Janssen J: Novel targeting strategy for generating mouse models with defects in the retinoid cycle. Vision Research. 2003; 43: 3075-3079.

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Kuksa V, Imanishi Y, Batten M, Palczewski K, Moise A: Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Research. 2003; 43: 2959-2981.

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Baehr W, Wu SM, Bird AC, Palczewski K: The retinoid cycle and retina disease. Vision Research. 2003; 43: 2957-2958.

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Stenkamp RE, Teller DC, Palczewski K: Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer. FEBS Letters. 2003; 555: 151-159.

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Heck M, Schadel S, Maretzki D, Bartl F, Ritter E, Palczewski K, Hofmann KP: Signaling states of rhodopsin: formation of the storage form, metarhodopsin III, from active metarhodopsin II. J Biol Chem 2003;278:3162-3169.