department of pharmacology

Krzysztof Palczewski, Ph.D.

2009 Publications

Moise RS, Alvarez S, Domínguez M, Alvarez R, Golczak M, Lobo GP, von Lintig J, de Lera AR, Palczewski K: Activation of retinoic acid receptors by dihydroretinoids. Mol. Pharma 2009, 76, 1128-1237. Supplement


Kiser PD, Lorimer GH, Palczewski K: Use of Thallium to Identify Monovalent Cation-Binding Sites in GroEL. Acta Crystallographica, 2009, F65, 967-971.


Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K : Crystal Structure of Native RPE65, the Retinoid Isomerase of the Visual Cycle. Proc. Natl. Acd. Sci. 2009, 106, 17325-17330. Supporting Information Commentary


Maeda A, Golczak M, Maeda T, Palczewski K: Limited roles of rdh8, rdh12 and abca4 on all-trans-retinal clearance in mouse retina. Invest. Ophthalmol. Visual Sciences 2009, 50, 5435-5443.


Maeda T, Maeda A, Matosky M, Roos S, Tang J, Palczewski K: Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance. Invest. Ophthalmol. Visual Sciences 2009, 50, 4917-4925.


Maeda T, Maeda A, Casadesus G, Palczewski K, Margaron P: Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. Invest. Ophthalmol. Visual Sciences 2009, 50, 4368-4378. Supplement


Angel TE, Gupta S, Jastrzebska B, Palczewski K, Chance MR: Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc. Natl. Acad. Sci. 2009, 106, 14367-14372.


Mustafi D, Engel AH, Palczewski K: Structure of Cone Photoreceptors. Progress Retinal and Eye Research, 2009, 28, 289-302.


Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG: Clarin-1 is essential for hair cell function and associated neural activation. Human Mol. Genetics 18, 2748-2760.


Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila E-M, Flannery JG, Imanishi Y: Clarin-1, encoded by the Usher syndrome III causative gene, forms a membranous microdomain that organizes the actin cytoskeleton. J. Biol. Chem 2009, 284, 18980-18993


Jastrzebska J, Goc A, Golczak M, Palczewski K: Phospholipids are needed for proper formation, stability and function of the photoactivated rhodopsin-transducin complex. Biochemistry 2009, 48, 5159-5170. Supplement


Palczewski K, Baehr W: Focus on Molecules: Guanylate Cyclase-Activating Proteins (GCAPs). Exp Eye Res 2009, 89, 2-3.


Angel TA, Chance MR, Palczewski K: Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc. Natl. Acad. Sci. 2009, 106, 8555-8560. Supplement


Maeda T, Cideciyan AV, Maeda A, Golczak M, Aleman TS, Jacobson SG, Palczewski K: Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Human Molecular Genetics 2009, 18, 2277-2287.


Maeda A, Maeda T, Golczak M, Chou S, Desai A, Hoppel CL, Matsuyama S, Palczewski K: Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J. Biol. Chem. 2009, 284, 15173-15183 supplement


Lodowski DT, Palczewski K: Chemokine receptors and other GPCRs. Current Opinion in HIV and AIDS 2009, 4, 88-95.


Park P, Sapra T, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono, M, Lem J, Crouch R, Filipek S, Müller D, Palczewski K: Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry 2009, 48, 4294-4304.


Lodowski DT, Angel TE, Palczewski K: Comparative analysis of GPCR Crystal Structures. Photochem and Photobiol. 2009, 85, 425-430


Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EAM, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K: Predicting ABCA4 disease progression: A strategy for gene therapy. Human Molecular Genetics 2009, 18, 931-941.
Supplementary Information


Mustafi D, Palczewski K: Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol Pharma 2009, 75, 1-12.


Maeda T, Maeda A, Leahy P, Saperstein DA, Palczewski K: Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. Invest. Ophthalmol. Visual Sciences 2009, 50, 322-333.

Supplemental Table 1
Supplemental Table 2

Li C, Chan J, Haeseleer F, Mikoshiba K, Palczewski K,Ikura M, Ames JB : Structural insights into Ca2+-dependent Regulation of inositol 1,4,5,-trisphosphate receptors by CaBP1. J Biol Chem 2009, 284, 2472-2481.

Jastrzebska J, Golczak M, Fotiadis D, Engel A, Palczewski K: Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin. FASEB J. 2009, 23, 371-381.

Supplemental Methods