department of pharmacology

Krzysztof Palczewski, Ph.D.

2010 Publications

Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K: Noninvasive multi-photon fluorescence microscopy resolves retinol and retinal-condensation products in mouse eyes. Nature Medicine 2010, 16: 1444-1450.
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Palczewski K: The blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch. Ophthalmol. 2010, 128: 1483-1485.


Huang J, Xu Z, Wang D, Ogato C, Hirama T, Palczewski K, Hazen SL, Lee X, Young NM Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Gycobiology 2010; 20:1643-1653.


Lodowski DT, Palczewski K, Miyagi M: Conformational changes in G protein-coupled receptor rhodopsin revealed by His hydrogen-deuterium exchange. Biochemistry 2010; 49: 9425-9427.


Palczewski K: Oligomeric forms of G protein-coupled receptors (GPCRs). Trends in Biochem. Sci. 2010, 35, 595-600


Golczak M, Palczewski K: An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase. J Biol. Chem. 2010, 285, 29217-29222.
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Pulagam LP, Palczewski K: Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J. Biol. Chem. 2010, 285, 29446-29456.


Lobo GP, Amengual J, Hessel S, Li H, Golczak M, Bonet ML, Palczewski K, von Lintig J: β, β-carotene decreases peroxisome proliferator receptor γ activity and reduces lipid storage capacity of adipocytes in a β, β-carotene-oxygenase 1-dependent manner. J. Biol. Chem. 2010, 285, 27891-27899.
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Tsybovsky Y, Molday RS, Palczewski K: The ATP-binding Cassette Transporter ABCA4: Structural and Functional Properties and Role in Retinal Disease: in Inflammation and Retinal Disease: Complement Biology and Pathology, Advances in Experimental Medicine and Biology 2010, 703, 8, 105-125. J.D. Lambris and A.P. Adamis (eds.), © Springer Science+Business Media, LLC.


Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K: Structural characterization of the rod cGMP phosphodiesterase 6. J. Mol. Biol. 2010, 401, 363-373.


Pulagam LV, Palczewski K: Phototransduction: rhodopsin. In: Darlene A. Dartt, editor. Encyclopedia of the Eye. Vol 3. Oxford: Academic Press; 2010. 403-412.


Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi L, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin J-P, Vriend G, Campagne F, Filizola M: GPCR-OKB: The G Protein Coupled Receptor - Oligomer Knowledge Base. Bioinformatics, 2010, 26, 1804-1805.
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Kiser PD, Palczewski K: Membrane-Binding and Enzymatic Properties of RPE65. Progress Retinal and Eye Research, 2010, 29, 428-442.


von Lintig J, Kiser PD, Golczak M, Palczewski K: The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochem. Sci. 2010, 35, 400-410.


Imanishi Y, Palczewski K: Visualization of Retinoid Storage and Trafficking by Two-Photon Microscopy. Methods in Molecular Biol. 2010, Retinoids: Methods and Protocols, 652, (Chapter 13; Humana Press), 229-243.


Golczak M, Bereta G, Maeda A, Palczewski K: Molecular biology and analytical chemistry methods used to probe the retinoid cycle visualization of retinoid storage and trafficking by two-photon microscopy. Methods in Molecular Biol. 2010, Retinoids: Methods and Protocols, 652, (Chapter 14; Humana Press), 247-261.


Palczewski K: Retinoids for Treatment of Retinal Diseases. Trends in Pharma. Sci. 2010, 31, 284-295.


Lobo GP, Hessel S, Eichinger A, Zongaro S, Noy N, Moise AR, Wyss A, Palczewski K, von Lintig J. ISX is a retinoic acid sensitive gatekeeper that controls intestinal β,β-carotene absorption and vitamin A production. FASEB J. 2010, 24, 1656-1666. Supplimental


Maeda A, Okano K, Park P P-H, Lem J, Crouch RK, Maeda T, Palczewski K: Palmitoylation stabilizes unliganded rod opsin. Proc. Natl. Acad. Sci. 2010, 107, 8428-8433. Supplement


Jastrzebska B, Tsybovsky Y, Palczewski K: Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J. 2010, 428, 1-10.


O’Byrne SM, Kako Y, Deckelbaum RJ, Hansen IH, Palczewski K, Goldberg IJ, Blaner WS:Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. Am. J. Physiol. Endocrinology and Metabolism 2010, E862-E870


Moise AR, Lobo GP, Erokwu B, Wilson DL, Peck D, Alvarez S, Domínguez M, Alvarez R, Flask CA, de Lera AR, von Lintig J, Palczewski K: Increased adiposity in the retinol saturase knockout mouse. FASEB J. 2010, 24, 1261-1270. Supplement


Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K: Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J. Biol. Chem. 2010, 285, 9667-9682.


Cao P, Yuan Y, Pehek EA, Moise AR, Huang Y, Palczewski K, Feng Z: Disruption of dopamine homeostasis results in dopaminergic neuron dysfunction and degeneration in Caenorhabditis elegans. PloS One 2010, 5, e9312-e9312.


Kevany BM, Palczewski K: Phagocytosis of Retinal Rod and Cone Photoreceptors. Physiology 2010, 25, 8-15.


Orban T, Gupta S, Palczewski K, Chance MR: Visualizing water molecules in transmembrane proteins. Biochemistry 2010,49, 827-834.


Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K: Conformational changes in guanylate cyclase-activating protein 1 (GCAP1) induced by Ca2+ and N-terminal fatty acid acylation. Structure 2010, 18, 116-126.
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Bereta G, Wang B, Kiser PD, Baehr W, Jang G-J, Palczewski K: Functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase J. Biol. Chem. 2010, 285, 1899–1908.
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