department of pharmacology

Krzysztof Palczewski, Ph.D.

2011 Publications

Jastrzebska B, Ringler P, Lodowski D, Moiseenkova-Bell V, Golczak M, Müller SA, Palczewski K, Engel A: Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. J. Struct. Biol. 2011, 176, 387-394
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Baker BY, Palczewski K: Detergents Stabilize the Conformation of Phosphodiesterase 6. Biochemistry 2011, 50, 9520-9531.
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Maeda T, Perusek L, Amangual J, Babino D, Palczewski K, von Lintig J: Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of Leber Congenital Amaurosis. Mol Pharmacol. 80, 943-952
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Salon JA, Lodowski DT, Palczewski K: The significance of GPCR crystallography for drug discovery.
Pharma. Reviews 2011, 63, 901-937

Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K: A sponge transgenic mouse model reveals important roles for the miRNA-183/96/182 cluster in post-mitotic photoreceptors of the retina. J. Biol. Chem. 2011,286, 31749-31760.
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Mustafi D, Kevany BM, Genoud C, Okano K, Cideciyan AV, Sumaroka A, Roman AJ, Jacobson SG, Engel A, Adams MD, Palczewski K: Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J. 2011, 25, 3157-3176.
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Lodowski TD, Palczewski K: The impact of G protein-coupled receptor (GPCR) structures on understanding signal transduction, in “G protein-coupled receptors: from structure to function. Giraldo J and Pin Jean-Philippe editors, 2011. The Royal Society of Chemistry. Drug discovery Series No 8. p3-27.

Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K: Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. Biochemistry 2011, 50, 6855-6866.

Salom D, Palczewski K: Structural biology of membrane proteins. In "Production of membrane proteins: strategies for expression and isolation." (ed. Anne Skaja Robinson) 2011, 9, 249-273. Wiley-VCH publisher.

Peshenko IV, Olshevskaya EV, Savchenko AB, Karan S, Palczewski K, Baehr W, Dizhoor AM. Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry 2011, 50, 5590-5600.

Jastrzebska J, Palczewski K, Golczak M: Role of bulk water in the hydrolysis of rhodopsin’s chromophore. J. Biol. Chem. 2011, 286, 19830-18937.

Mustafi D, Avishai A, Avishai N, Engel A, Heuer A, Palczewski K: Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J. Neuroscience Methods 2011, 198, 70-76.

Bereta G, Palczewski K: Heterogeneous N-terminal Acylation of Retinal Proteins Results from the Retina’s Unusual Lipid Metabolism. Biochemistry 2011, 50, 3764-3776.

Orban T, Palczewska G, Palczewski K: Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J. Biol. Chem. 2011, 286, 17248-17258.
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Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A.: Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J. Biol. Chem. 2011, 286, 15543-15555.
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Jastrzebska B, Debinski A, Filipek S, Palczewski K: Role of Membrane Integrity on G protein-coupled Receptor Rhodopsin Stability and Function. Progress in Lipid Research 2011, 50, 267-277.

Sakami S, Maeda T, Bereta G, Okano K, Golczak M, Sumaroka A, Roman AJ, Cideciyan AV, Jacobson SG, Palczewski K: Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J. Biol. Chem. 2011, 286, 10551-10567.
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Sanae Sakami

Huang C-C, Orban T, Jastrzebska B, Palczewski K, Tesmer JJG: Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry 2011, 50, 1940-1949.

Amengual J, Lobo GP, Golczak M, Hessel S, Li NHM, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J: A Mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J 2011,25, 948-959.
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Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA: Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. J. Biol. Chem. 2011, 286, 5607-5613. Supplement

Palczewski K: Focus on vision: three decades of remarkable contributions to biology and medicine. FASEB J 2011, 25, 439-443.

Li H, Palczewski K, Baehr W, Clagett-Dame M: Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biology of Reproduction. 2011, 84, 336-341.

Hunter JJ, Masella B, Dubra A, Sharma R, Yin L, Merigan WH, Palczewska G, Palczewski K, Williams DR: Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomedical Optics Express 2011, 2, 139-148.