department of pharmacology

Krzysztof Palczewski, Ph.D.

2013 Publications

Kevany B.M., Y. Tsybovsky, I.D.G. Campuzano, P. D. Schnier, A. Engel, and K. Palczewski. Structural and functional analysis of the native peripherin/ROM1 complex isolated from photoreceptor cells. J. Biol. Chem. 2013, 288, 36272-36284.

Chen Y., G. Palczewska, D. Mustafi, M. Golczak, Z. Dong, O. Sawada, T. Maeda, A. Maeda, and K. Palczewski, Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. J Clin Invest 2013, 123, 5119-5134.
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Maeda T., M. J. Lee, G. Palczewska, S. Marsili, P. Tesar, K. Palczewski, M. Takahashi, and A. Maeda. Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo. J. Biol. Chem. 288, 34484-34493.

Amengual J, M., M. A. K, Widjaja-Adhi, S. Rodriguez-Santiago , S. Hessel, M. Golczak, K. Palczewski, J. von Lintig (2013) Two carotenoid-oxygenases contribute to mammalian pro-vitamin A metabolism. J, Biol. Chem. 2013, 288:34097.

Mustafi, D, B. M.Kevany, C. Genoud, X. Bai, K. Palczewski. Photoreceptor phagocytosis is mediated by phosphoinositide signaling. FASEB J 2013, 27, 4585-4595.

Sui, X., P.D. Kiser, J. von Lintig, and K. Palczewski, Structural basis of carotenoid cleavage: from bacteria to mammals. Archives Biochem. Biophys 2012, 539, 203-213.

Kowatz, T, D. Babino, P. Kiser, K. Palczewski, and J. von Lintig, Characterization of human β,β-carotene-15,15´ monooxygenase (BCMO1) as a soluble monomeric enzyme. Archives Biochem. Biophys 2013, 539, 21-222.

Salom D., P. S. Padayatti, and K. Palczewski, Crystallization of G protein-coupled receptors. Methods in Cell Biology 2013, 117, 451-468.

Du Y., A. Veenstra, K. Palczewski, and T. S. Kern, Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc. Natl. Acd Sci. 2013, 110, 16586–16591.

Helbling R., C. Bolze, M. Golczak, K. Palczewski, A. Stocker, and M. Cascella. Cellular Retinaldehyde Binding Protein - Different Binding Modes and Micro-Solvation Patterns for High-Affinity 9-cis and 11- cis-Retinal Substrates. J. Phys. Chem. 2013, 117, 10719-10729.

Palczewski K, and T. Orban, From Atomic Structures to Neuronal Functions of G protein-coupled receptors (GPCRs). Annu Rev Neurosci 2013. 36, 139-164.

Sharma, R., L. Yin, Y. Geng, W. H. Merigan,G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, In vivo two-photon imaging of the mouse retina. Biomedical Optics Express 2013.4, 1285-1293.

Mustafi D., B.M. Kevany, X. Bai, T. Maeda, J. E. Sears, A. M. Khalil, and K. Palczewski: Evolutionarily conserved long intergenic non–coding RNAs in the eye. Hum Mol Genetics 2013. 22, 2992-3002.
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Kohno, H., Y. Chen, B. M. Kevany, E. Pearlman, M. Miyagi, T. Maeda, K. Palczewski, and A. Maeda: Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J. Biol. Chem. 2013, 288, 15326-15341.

Tsybovsky Y., T. Orban, R. S., Molday, D. Taylor, and K. Palczewski, Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Structure 2013,21: p. 854-860.
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Padayatti P.S., L. Wang, S. Gupta, T. Orban, W. Sun, D. Salom, S. Jordan, K. Palczewski, and M. R. Chance, A hybrid structural approach to analyze ligand binding by the 5-HT4 receptor. Molecular and Cellular Proteomics, 2013, 12, 1259 1271.
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Palczewski, K., and P. D. Kiser, As good as chocolate. Science 2013, 340, 562-563.

Jastrzebska B., P. Ringler, K. Palczewski, and A. Engel, The rhodopsin-transducin complex houses two distinct rhodopsin molecules. J. Struct. Biol. 2013, 182, 164-172.
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Yan J, S. Kaur, D. DeLucia, C. Hao, J. Mehrens, C. Wang, M. Golczak, K. Palczewski, A. M. Gronenborn, J. Ahn, and J. Skowronski, Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J. Biol. Chem. 2013, 288:p.10406-10417.
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Tian M, Zallocchi M, Wang W, Chen C-K, Palczewski K, Duane Delimont D, Cosgrove D, You-Wei Peng Y-W. Light-Induced Translocation of RGS9-1 and Gβ5L in Mouse Rod Photoreceptors. PLoS ONE, 2013, 8(3): e58832.

Jastrzebska, B., T. Orban, M. Golczak, A. Engel, and K. Palczewski. Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J, 2013, 27: 1572-1584.

Vahedi-Faridi, A., B. Jastrzebska, K. Palczewski, and A. Engel, 3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy. J Electron Microsc (Tokyo), 2013, 62(1):p. 95 107.

Jastrzebska, B., D. Salom, H. Jin, P. Cao, W. Sun, K. Palczewski, and Z. Feng, Expression of Mammalian G Protein Coupled Receptors in Caenorhabditis elegans. Methods Enzymol, 2013. 520C: p. 239-256.

Maeda, T., Z. Dong, H. Jin, O. Sawada, S. Gao, D. Utkhede, W. Monk, G. Palczewska, and K. Palczewski, QLT091001, a 9-cis-Retinal Analog, Is Well-Tolerated by Retinas of Mice with Impaired Visual Cycles. Invest Ophthalmol Vis Sci, 2013. 54(1): p. 455-66.

Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K: Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clinical Invest. 2013 123, 121-137.
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