department of pharmacology

Krzysztof Palczewski, Ph.D.

2017 Publications

Chiang, C-K., A. Tworak, B. M. Kevany, B. Xu, J. Mayne, Z. Ning, D. Figeys, K. Palczewski. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium.. J Biol Chem 2017,292, 19826-19839
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Penberthy, K., C. Rival, L. Shankman, M. Raymond, J. Zhang, J. Perry, C. Han, S. Onengut-Gumuscu, K. Palczewski, J. Lysiak, and K. Ravichandran. Context-dependent compensation among phosphatidylserine-recognition receptors. Scientific Reports 2017, 7,1-14
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Kolesnikov, A. V., T. Orban, H. Jin, C. Brooks, L. Hofmann, Z. Dong, M Sokolov, K. Palczewski, V.J. Kefalov. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc. Natl. Acd. Sci 2017 E9675-E9684
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Alexander, N.S., K. Palczewski, Crowd sourcing difficult problems in protein science. Protein Sci 26, 2118-2125

Chan S. H. C., D. McCarthy J. Li, K. Palczewski, S. Yuan. Designing safer analgesics via µ-opioid receptor pathways. Trends in Pharma Sci 2017, 38, 1016-1037

Murashova, G. A., C. A. Mancuso, J. l. Canfield, S. Sakami, K. Palczewski, G. Palczewska, M. Dantus, Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomedical Optics Express 2017, 8, 5228-5242
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Tonade, D., H. Liu, K. Palczewski, T.S. Kern, Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in diabetes. Diabetologia 2017, 60, 2111-2120

Sears, A. E., P. S. Bernstein, A.V. Cideciyan, C. Hoyng, P. C. Issa; K. Palczewski, P. J. Rosenfeld, S. Sadda, U. Schraermeyer, J. R. Sparrow, I. Washington, H. P. N. Scholl. Towards treatment of Stargardt disease: workshop organized and sponsored by the Foundation Fighting Blindness. Trans Vis Sci Tech. 2017;6 (5):6

Palczewski, K. Skunkworks project for Big Pharma. Pharmacological Research. 2017,124, 167-168

Alexander, N. S., K. Katayama, W. Sun, D. Salom, S. Gulati, J. Zhang, M. Mogi, K. Palczewski, and B. Jastrzebska. Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. J. Biol. Chem. 2017, 292, 10983-10997.

Kiser, P.D., J. Zhang, M. Badiee, J. Kinoshita, N. S Peachey, G. P Tochtrop, and K. Palczewski. Rational tuning of visual cycle modulator pharmacodynamics. J. Pharm. Exp. Therap. 2017, 362, 131-145

Sui, X., A. Weitz, E. Farquhar, M. Badiee, S. Banerjee, J. von Lintig, G. Tochtrop, K. Palczewski, M. Hendrich, P. D. Kiser. Structure and spectroscopy of alkene-cleaving dioxygenases containing an atypically coordinated non-heme iron center. Biochemistry 2017, 56, 2836-2852.
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Xue Y., S. Sato, D. Razafsky, B. Sahu, S.Q. Shen, L.L. Sandell, J. C. Corbo, K. Palczewski, A. Maeda, D. Hodzic, and V. J. Kefalov. The role of retinol dehydrogenase 10 in the cone visual cycle. Scientific Reports 2017 7: 2390 | DOI:10.1038/s41598-017- 02549-8
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Hofmann, L., N. S. Alexander, W. Sun, J. Zhang, T. Orban, and K. Palczewski. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry 2017, 56, 2338–2348
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Gulati S., B. Jastrzebska, S. Banerjeec, Á. L. Placeres, P. Miszta, S. Gao, K. Gunderson, G. Tochtrop, S. Filipek, K. Katayama, P. D. Kisera, M. Mogi, P.L. Stewart, K. Palczewski. Photocyclic behavior of rhodopsin induced by a novel isomerization mechanism. Proc. Natl. Acd. Sci. 2017, E2608-E2615
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Sun D., B. Sahu, S. Gao, R. Schur, A. Maeda, K. Palczewski, Z-R. Lu. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber’s Congenital Amaurosis. Molecular Therapy - Nucleic Acids, 2017, 7, 42-52.

G. A. Murashova, C. A. Mancuso, S. Sakami, K. Palczewski, G. Palczewska, M. Dantus. Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proc. of SPIE Vol. 10069 100692K-1 doi: 10.1117/12.2252457.

Athanasiou D, M. Aguila, C. A. Opefi, K. South, J. Bellingham, D. Bevilacqua, P. M. Munro, N. Kanuga1, F. E. Mackenzie, A. M. Dubis, A. Georgiadis, A.B. Graca, R. A. Pearson1, R. R. Ali, S. Sakami, K. Palczewski, M. Y. Sherman, P. J. Reeves, M. E. Cheetham. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum. Mol. Genetics 2017, 26, 305-319.
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Sundermeier T.R., S. Sakami, B. Sahu, S.J. Howell, S. Gao, Z. Dong, M. Golczak, A. Maeda, and K. Palczewski. microRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J. Biol. Chem. 2017, 3366-3378.

Sharma R., C. Schwarz, J.J. Hunter, G. Palczewska, K. Palczewski, D. R. Williams. Formation and clearance of all-trans-retinol in rods investigated in the living primate eye with two-photon ophthalmoscopy. Invest. Ophthalmol. Vis. Res. 2017,58, 604-613.

Jastrzebska B, W.D. Comar, M. J. Kaliszewski, K. C. Skinner, M.H. Torcasio, A. S. Esway, H. Jin, K. Palczewski, A. W. Smith. A GPCR dimerization interface in human cone opsins. Biochemistry 2017, 56, 61-72. Biochemistry 2017, 56, 61-72.
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Chen Y., M. J. Brooks, L. Gieser, A. Swaroop, K. Palczewski. Transcriptome Profiling of NIH3T3 Cell Lines Expressing Opsin and the P23H Opsin Mutant Identifies Candidate Drugs for the Treatment of Retinitis Pigmentosa. Pharmacological Research 2017, 115, 1-13.
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