PHARMACOLOGY

Secondary Faculty

Jeffrey L. Blumer, M.D., Ph.D., Professor

Pediatric clinical pharmacology, pharmacokinetics and clinical trials. Genetic and developmental aspects of drug metabolism related to birth defects and pediatric cancers

Robert A. Bonomo, M.D., Associate Professor

Structure function studies of Class A beta-lactamases. Understanding enzymological factors that permit the successful evolution of beta-lactamases in the clinic. Development of immunological tools to study beta-lactamase expression in enteric bacilli.

Matthias Buck, Ph.D., Assistant Professor

We characterize the structures and the dynamics of proteins involved in protein-protein interactions. It is these features that determine the basic mechanisms by which proteins transmit signals in cells.

David Danielpour, Ph.D., Associate Professor

Function and regulation of TGF-β in the prostate.

Clark W. Distelhorst, M.D., Professor

Steroid hormone action; programmed cell death; apoptosis.

George R. Dubyak, Ph.D., Professor

Signal transduction involving receptors for extracellular ATP; inflammatory signal transduction mechanisms; mechanisms of nucleotide release and extracellular metabolism.

Subrata Haldar, Ph.D., Associate Professor

Growth factor control of apoptosis.

Thomas J Kelley, Ph.D., Assistant Professor

Inflammatory cell signaling pathways associated primarily with cystic fibrosis, along with signaling mechanisms associated with intracellular cholesterol transport regulation.

Timothy S. Kern, Ph.D., Professor

Pathogenesis and prevention of retinopathy and other complications of diabetes; vascular cell apoptosis.

Alan D. Levine, Ph.D., Professor

Host defense in the gastrointestinal tract: Regulation of T cell differentiation and activation, epithelial cells as antigen presenting cells, apoptosis in the intestinal epithelium, Modulation of T cell responses by the extracellular matrix, animal models of inflammatory bowel disease.

Shigemi Matsuyama, Ph.D., Assistant Professor

Programmed Cell Death, Cancer Cell Biology, Aging Mechanism, DNA Repair, Membrane Traffic control, Cell Penetrating Peptides.

Danny Manor, Ph.D., Associate Professor

Regulation of cell growth and oncogenesis, GTPase-mediated signaling, vitamin E biology

Philip Morgan, M.D., Professor

Our lab is interested in the mechanism of action of volatile anesthetics and in ageing. We use a genetic approach studying the nematode, C. elegans.

Ram H. Nagaraj, Ph.D., Professor

Protein modification by sugar and sugar metabolites; chemical modification of lens proteins during cataract formation; retinal microvascular cell damage in hyperglycemia; inhibition of sugar-mediated protein damage by molecular and chemical approaches

Jun Qin, Ph.D., Professor

Cellular signaling mechanisms, Biomolecular NMR spectroscopy, protein-protein and protein-nucleic acid interactions

Michael D.Reed, PharmD, Pediatrics

Metabolic-mediated drug interactions in children.

Greg Tochtrop, Ph.D., Assistant Professor

Chemical Interrogation of FXR Function, Diversity Oriented Synthesis, Proteome Wide Binding Assays.

Bingcheng Wang, Ph.D., Associate Professor

Molecular mechanisms governing cell migration and proliferation, experimental therapy of cancer metastasis using tumor-targeting peptides.

Vivien C. Yee, Ph.D., Associate Professor

Our laboratory seeks to use X-ray crystallographic methods to determine and analyze the structures of biomedically important proteins and of enzymes with interesting mechanistic questions. Some of our current projects focus on proteins involved in blood clotting, neurodegenerative disorders and antiviral defense, or are model systems for metabolic enzymes.