department of pharmacology

Secondary Faculty

Robert Bonomo, M.D. Professor of Medicine, Pharmacology, and Molecular Biology and Microbiology
Phone: (216) 791-3800 x4399 Fax: (216) 229-8509
Research: Structure function studies of Class A beta-lactamases. Understanding enzymological factors that permit the successful evolution of beta-lactamases in the clinic. Development of immunological tools to study beta-lactamase expression in enteric bacilli.

Matthias Buck, Ph.D. Professor
Phone: (216) 368-8651 Fax: (216) 368-1693
Research: We characterize the structures and the dynamics of proteins involved in protein-protein interactions. It is these features that determine the basic mechanisms by which proteins transmit signals in cells.

David Danielpour, Ph.D. Professor of General Medical Sciences/Oncology and Pharmacology
Phone: (216) 368-5670 Fax: (216) 368-8919
Research: Function and regulation of TGF-β in the prostate.

Clark Distelhorst, M.D. Charles S. Britton II Professor of Hematology/Oncology
Phone: (216) 368-4546 Fax: NA
Research: Steroid hormone action; programmed cell death; apoptosis.

George Dubyak, Ph.D. Professor
Phone: (216) 368-5523 Fax: (216) 368-5586
Research: Signal transduction involving receptors for extracellular ATP; inflammatory signal transduction mechanisms; mechanisms of nucleotide release and extracellular metabolism.

Rose Gubitosi-Klug, M.D., Ph.D. Associate Professor and Interim Chief, Pediatric Endocrinology Mary Blossom Lee Chair in Pediatric Diabetes PI, EDIC Clinical Coordinating Center Case Western Reserve University Rainbow Babies and Childrens Hospital
Phone: 216-844-3661 Fax: 216-844-8900
Research: Dr. Gubitosi-Klug's basic and clinical research focuses on the role of the leukotriene cascade in early diabetic retinopathy. Animal models of diabetes have demonstrated the critical role of leukotrienes in triggering chronic inflammation in the retina; this inflammatory insult damages capillaries. Based on these animal models, biomarkers of early diabetic retinopathy are being studied in adolescents with diabetes.

Thomas Kelley, Ph.D. Associate Professor
Phone: (216) 368 0831 Fax: NA
Research: Inflammatory cell signaling pathways associated primarily with cystic fibrosis, along with signaling mechanisms associated with intracellular cholesterol transport regulation.

Alan Levine, Ph.D. Professor
Phone: (216) 368-0342 Fax: (216) 368-3055
Research: Intestinal Host Defense: Toggling between immune tolerance and immune

Stephen J. Lewis, Ph.D. Professor of Pediatrics
Phone: 216-368-3482 Fax: 216-368-4223
Research: My laboratory focuses on the roles of endogenous S-nitrosothiols such as S-nitrosocysteine and S-nitrosoglutathione in the control of breathing and hemodynamic function in mice and rats.

David Lodowski, Ph.D. Assistant Professor
Phone: (216) 368-6971 Fax: (216) 368-6846
Research: The Lodowski laboratory employs a combination of x-ray crystallography and electron microscopy techniques to explore the mechanisms of GPCR and G protein activation.

Akiko Maeda, Ph.D.
Phone: 216-368-0670 Fax:

Danny Manor, Ph.D. Associate Professor
Phone: (216) 368-6230 Fax: (216) 368-6644
Research: Regulation of cell growth and oncogenesis, GTPase-mediated signaling, vitamin E biology

Shigemi Matsuyama, Ph.D Associate Professor, Medicine
Phone: (216) 368-5832 Fax: (216) 368-8919
Research: Programmed Cell Death, Cancer Cell Biology, Aging Mechanism, DNA Repair, Membrane Traffic control, Cell Penetrating Peptides.

Masaru Miyagi, Ph.D Assistant Professor
Phone: (216) 368-5917 Fax: (216) 368-6846
Research: Molecular mechanisms of retinal light damage and development of proteomic methods.

Paul Park, Ph.D. Assistant Professor
Phone: (216) 368-2533 Fax:
Research: The goal of Park laboratory is to understand the mechanism of signal transmission at the molecular level in phototransduction and other G protein-coupled receptor-mediated signaling systems.

Irina Pikuleva, Ph.D. Professor
Phone: (216) 368-3823 Fax:
Research: Research deals to understand how cholesterol-metabolizing P450s function at the molecular level, what roles the four cytochrome P450 enzymes 7A1, 27A1, 46A1, and 11A1 play in the development of different diseases, and whether these enzymes could serve as targets for cholesterol lowering medications.

Jun Qin, Ph.D. Professor
Phone: (216) 444-5392 Fax: (216) 445-1466
Research: Cellular signaling mechanisms, Biomolecular NMR spectroscopy, protein-protein and protein-nucleic acid interactions

William P. Schiemann, Ph.D. Associate Professor
Phone: (216)368-5763 Fax: NA

Nima Sharifi, M.D. Kendrick Family Endowed Chair for Prostate Cancer Research Department of Cancer Biology, Lerner Research Institute Department of Solid Tumor Oncology, Taussig Cancer Institute Glickman Urological and Kidney Institute Cleveland Clinic
Phone: (216) 445-9750 Fax:
Research: Our laboratory is focused on steroid metabolism and androgen receptor (AR) function as it relates to prostate cancer. The first line of therapy for metastatic prostate cancer is androgen deprivation therapy (ADT), which blocks the release of gonadal testosterone and suppresses intratumoral concentrations of the most potent androgen, dihydrotestosterone (DHT). However, metastatic disease eventually becomes resistant to ADT. Prostate cancer that progresses in the face of ADT is termed castration-resistant prostate cancer (CRPC) and is frequently driven by tumors acquiring the capability of making their own DHT. We study how this process occurs. Our most important discoveries include identification of the first mutation in the androgen synthesis machinery that is responsible for increasing DHT synthesis in CRPC and demonstration that DHT synthesis in patients with CRPC follows a pathway that circumvents testosterone. We are currently applying these findings to the study of CRPC as it occurs in patients.

Gregory Tochtrop, Ph.D. Assistant Professor
Phone: (216) 368-2351 Fax: NA
Research: Chemical Interrogation of FXR Function, Diversity Oriented Synthesis, Proteome Wide Binding Assays.

Bingcheng Wang, Ph.D. Professor
Phone: (216) 778-4256 Fax: (216) 778-4321
Research: Molecular mechanisms governing cell migration and proliferation, experimental therapy of cancer metastasis using tumor-targeting peptides.

Sichun Yang, Ph.D. Assistant Professor
Phone: (216) 368.5793 Fax:
Research: Structure and function of nuclear estrogen receptors; small-angle x-ray solution scattering; computational biophysics; structure-based ligand screening

Vivien Yee, Ph.D Associate Professor
Phone: (216) 368-1184 Fax: (216) 368-3419
Research: Our laboratory seeks to use X-ray crystallographic methods to determine and analyze the structures of biomedically important proteins and of enzymes with interesting mechanistic questions. Some of our current projects focus on proteins involved in blood clotting, neurodegenerative disorders and antiviral defense, or are model systems for metabolic enzymes.