AVisvha Dixit, Ph.D.
Early Discovery Research Department
S. San Francisco, CA
Dixit's pioneering studies defined the biochemical framework illuminating many of
the key components of the cell death pathway. He identified numerous proteins in
the cell death cascade and determined how they functioned at a molecular level.
It was previously thought that receptors signal either by serving as ion channels
or by altering phosphorylation-dephosphorylation events. Work in the Dixit laboratory
conclusively showed that death domain containing receptors signal apoptosis by an
entirely new mechanism, specifically, the adapter (FADD) mediated recruitment and
activation of death proteases (caspase-8).