Keri Laboratory
Gene Expression
Tumor formation, growth, and progression requires an orchestrated set of events that ultimately impinge upon the nucleus and control the ensemble of genes that are expressed. This requires the activation and suppression of specific transcription factors which serve as "nodal points" for the regulatory circuitry of the cell. We have identified several transcription factors/modulators whose expression is altered in mammary tumors compared to normal mammary glands and are currently assessing the role of these regulators in tumor cell function. We are particularly interested in the network of factors that contribute to the gene expression hierarchy involved in HER2/Neu-induced tumorigenesis. Proteins of current interest are Id1, Id2, LMO4, KLF4, and FoxA1.
Members:
Jennifer YoriGraduate Student |
Kristen LozadaResearch Assistant |
Marjorie Montanez-WiscovichGraduate Student |
Darcie SeachristResearch Assistant |
Jonathan MosleyGraduate Student |
Gina BernardoGraduate Student |
Melanie LynchInstructor |
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Melissa Landis (Keri Lab Alumnus) Erin Milliken (Keri Lab Alumnus) |
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