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department of pharmacology

Register for the Pittsburgh Diffraction Conference

Please join us for talks, posters and vendor presentations at the 76th Annual Pittsburgh Diffraction Conference Case Western Reserve University.
Register Now!
Find out more
Posted On 7/19/2018 - Archived On 10/16/2018

Hoppel Prize for Outstanding Contributions in Mitochondrial Research

Congratulations to Michael R. Duchen, winner of the 2018 Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research! Read more about Dr. Duchen.

Find out more about the Charles L. Hoppel, MD Endowment in Mitochondrial Biology on our webpage!
Posted On 7/2/2018 - Archived On 12/1/2018

The Second Annual Charles L. Hoppel, M.D. Award for Outstanding Contributions in Mitochondrial Research

This Award was inaugurated to honor Dr. Hoppel’s service to Case Western Reserve University School of Medicine, and his outstanding career in mitochondrial biology as researcher, educator and mentor. Nominations for the 2018 Charles L. Hoppel Award are due by Monday, April 30, 2018 >>
Posted On 3/28/2018 - Archived On 5/25/2018

Yoshikazu Imanishi invited as a visiting professor at Harvard Medical School and Boston Children's hospital to give lecture.

See their Visiting Professor Lecture Series >
Posted On 10/27/2017 - Archived On 12/31/2017

Lighthouse Guild gave two awards to faculty members from the same university.

Dr. Palczewski got the Bressler award in 2015 & Dr. Imanishi recently was awarded the Pisart award earlier this year.
Posted On 10/27/2017 - Archived On 12/31/2017

Dr. Palczewski receives the 2017 Maria Sklodowska-Curie Medal!

At the Polish Chemical Society Meeting In Poland.
Posted On 10/27/2017 - Archived On 12/31/2017

SAVE THE DATE – September 28-29, 2017 - Annual Retreat

Get the details...dates, deadlines, abstract info and more.
Posted On 7/14/2017 - Archived On 9/28/2017

Welcome Professor Yu!

The Pharmacology Faculty Search Committee with the support of Krzysztof Palczewski, Ph.D., Professor & Chair of Pharmacology announce the appointment of its newest faculty member, Edward W. Yu, Ph.D. who will join the department on September 1, 2017. Dr. Yu will join us from Iowa State University. He is an outstanding crystallographer widely known in the fields of membrane protein structural biology with an expertise in metal transport.
Posted On 7/14/2017 - Archived On 9/2/2017

SAVE THE DATE – October 6-7, 2016 - Annual Retreat

Get the details...dates, deadlines, abstract info and more.
Posted On 5/25/2016 - Archived On 10/6/2016

Dr. Palczewski Honored!

On Thursday, April 21, 2016 the President and Provost honored Dr. Palczewski as the Distinguished University Professor.
Posted On 5/3/2016 - Archived On 6/2/2017

10 Years as Chairman!

CONGRATULATIONS to Dr. Palczewski who just celebrated his 10th year of serving as Chair of Pharmacology!
Posted On 11/3/2015 - Archived On 11/3/2016

Bressler/Lighthouse Foundation Award

Congratulations to Dr. Palczewski for his recent award from the Bressler/Lighthouse Foundation --- the only winner from a pool of international candidates who study vision!
Posted On 11/3/2015 - Archived On 12/3/2016

Celebrating Professor Krzysztof Palczewski's Ten Years as Chair of the Department of Pharmacology

The Dean's Scientific Research Symposium in honor of Prof. Krzysztof Palczewski will be held on Oct 19th, 2015. in the Tinkham Veale University Center. Find out more!
Posted On 9/30/2015 - Archived On 10/19/2015

Department of Pharmacology Retreat 2015

Thursday, October 29th 8:30am - Friday, October 30th 4:30pm
Get more info > | Register now >
Posted On 7/16/2015 - Archived On 9/1/2015

Kris Palczewski receives prestigious award

Congratulations! Kris Palczewski receives one of only five grants awarded by the NIH in it's prestigious Audacious Initiatives Program! READ MORE
Posted On 5/4/2015 - Archived On 10/3/2015

CONGRATULATIONS to our Chair, Krzysztof Palczewski who is the 2015 recipient of the BRESSLER AWARD

CONGRATULATIONS to our Chair, Krzysztof Palczewski who is the 2015 recipient of the BRESSLER AWARD, sponsored by the Lighthouse Guild! The recipient is selected among international scientists and clinicians whose contributions have advanced vision care and whose further work is expected to continue and contribute significantly! Congratulations Kris!
Posted On 3/5/2015 - Archived On 11/1/2015

A Pharmacology professor wins the Diekoff Award!

Congratulations to Dr. Paul MacDonald who was recognized for his excellence in graduate education. Dr. MacDonald was awarded the John S. Diekoff Award to Faculty for Excellence in Teaching. This award is extra special because the graduate students make the nominations and selection and they have experienced his teaching first hand! Dr. MacDonald joins the list of distinguished educators at Case Western Reserve University.

Posted On 5/19/2014 - Archived On 3/31/2015

The Department of Pharmacology is in the news again!

We just can't be stopped. Our department is featured twice in the December issue of Aspet's "The Pharmacologist". Student Andrea Boyd-Tressler on p. 224 and the GPCR meeting organized by our own Marvin Nieman, David Lodowski and Paul Park on p. 234-235. Check it out!

http://www.aspet.org/The_Pharmacologist.aspx?utm_source=The+Pharmacologist+December+2013&utm_campaign=The+Pharmacologist+-+Dec2013&utm_medium=email
Posted On 12/12/2013 - Archived On 3/11/2014

Game-changing discoveries from the Palczewski lab and the School of Medicine

A video featuring scientists Cameron McIntyre, Paul Tesar, Kris Palczewski, Mark Griswold and Jerry Silver demonstrates some of the school's most exciting emerging breakthroughs.

Check it out on the video link to your right.

Posted On 11/15/2013 - Archived On 8/15/2014

Check us out on Facebook!

www.facebook.com/CWRUPharmacology
Posted On 11/15/2013 - Archived On 11/15/2014

Grad Student Michele Mumaw Selected for Abstract Achievement Award

Michele’s work was selected as an Abstract Achievement Award by the American Society of Hematology and will be presented at the ASH Annual Meeting in New Orleans on December 8th.

"An Antibody Targeted To The Anionic Region Of Human Protease Activated Receptor 4 Inhibits Thrombosis Without Influencing Bleeding".

Posted On 10/30/2013 - Archived On 12/10/2013

Feng lab published in Cell Metabolism

In this paper titled "Functional Aging in the Nervous System Contributes to Age-Dependent Motor Activity Decline in C. elegans.", they found that functional ageing in the nervous system but not muscles is responsible for the age-dependent motor activity decline in worms. Thus, it is possible to stimulate the nervous system to improve physical activity in aged organisms.
Posted On 10/9/2013 - Archived On 11/8/2013

Cleveland Clinic researcher and secondary faculty member in Pharmacology, Dr. Nima Sharifi, discovers genetic mutation in deadly form of prostate cancer

These interesting findings are reported in Cell 154, 1074–1084, August 29, 2013. For more information, visit http://www.cleveland.com/healthfit/index.ssf/2013/08/cleveland_clinic_researcher_di.html#incart_river
Posted On 9/4/2013 - Archived On 10/4/2013

Case Western Reserve University honors incoming PhD Students

Case Western Reserve University Among First Universities to Honor PhD Students with White Lab Coat Ceremony

For the first time, PhD students at Case Western Reserve University's School of Medicine were honored with a white coat ceremony of their own. On Friday, August 24, PhD students and their families joined School of Medicine faculty to receive their own dedicated white lab coats, honoring their acceptance into the professional world of scientific research. For more info and photos, go to:

http://casemed.case.edu/newscenter/news/phd-whitecoat/

Posted On 8/28/2013 - Archived On 9/27/2013

Gene offers athlete’s heart without the exercise—and suppresses spread of breast cancer

The Montano lab has discovered the suppressive effects of the gene HEXIM1 on breast cancer in mouse models. Now they have demonstrated that it also enhances the number and density of blood vessels in the heart—a sure sign of cardiac fitness.

For more info, visit the Daily:

thedaily.case.edu/news/?p=18351

or go to: http://www.foxnews.com/health/2013/06/14/newly-discovered-gene-strengthens-heart-fights-breast-tumors/

Posted On 6/24/2013 - Archived On 8/5/2013

Amy Wilson-Delfosse does it again!

Congratulations to Dr. Amy Wilson-Delfosse who was once again recognized for her excellence in medical education. Dr. Wilson-Delfosse was awarded the Kaiser-Permanente Award for Excellence in Teaching. This award is extra special because the medical students make the selection and they have experienced her teaching first hand!

It's a great place to work and learn!
Posted On 6/6/2013 - Archived On 8/6/2013

The Department of Pharmacology welcomes our SURP Students

The Summer Undergraduate Research Program is underway. Welcome to the participating students! Here's to a wonderful summer--it's a great place to work!
Posted On 5/29/2013 - Archived On 6/10/2013

Andrea Boyd-Tressler Wins at the BGSS

Andrea wins a prize for her poster presented at the Biomedical Graduate Student Symposium. The poster was entitled: "Pro-apoptotic agents induce ATP release from leukemia/ lymphoma tumor cells via pannexin-1 dependent and pannexin-1 independent mechanism". Congratulations on a job well done!
Posted On 5/13/2013 - Archived On 6/12/2013

Krzysztof Palczewski Receives Pretigious Award!

Dr. Krzysztof Palczewski receives the 2013 Faculty Research Award for excellence in research. President Barbara Snyder, Dean Pam Davis, and Provost and Executive Vice President, William A. "Bud" Baeslack III, award Kris with this pretigious honor! His lab group and faculty members gathered to congratulate him.

Posted On 5/12/2013 - Archived On 7/25/2013

Congratulation Will!

Will Johnson, a graduate student working in the laboratories of Amy Wilson-Delfosse and John Mieyal is awarded a Parkinson's Disease Foundation Student Fellowship. Good Job Will!
Posted On 4/29/2013 - Archived On 5/29/2013

Gary Landreth, a trainer in Pharmacology, receives license for Alzheimer's treatment

CWRU research spinoff ReXceptor receives exclusive license for Alzheimer’s disease treatment

Case Western Reserve’s Technology Transfer Office has granted an exclusive license of a novel Alzheimer’s disease treatment strategy to spinoff company ReXceptor Inc., which plans to initiate early-stage human clinical trials of the medication within the next few months. Professor Gary Landreth and his then-graduate student, Paige Cramer, co-founded ReXceptor after discovering that bexarotene reversed AD symptoms in mice within 72 hours of a single dose of treatment.

Learn more here: http://cwru-daily.com/news/cwru-research-spinoff-rexceptor-receives-exclusive-license-for-alzheimers-disease-treatment-2/
Posted On 4/29/2013 - Archived On 5/29/2013

Welcome to Pharmacology at CWRU

Our mission is to discover specific mechanisms that control physiological processes at the cellular and molecular level. Our basic science approach is the best framework for rational drug design, and our research offers hope for defeating some of humanity's most devastating diseases--breast cancer, AIDS, blindness, hypertension, Alzheimer's, and diabetes.

The mission of our Department encompasses research and education in molecular, cellular, and clinical pharmacology. We actively participate in five specialized research centers associated primarily with the Department of Pharmacology and we are committed to supporting the community of faculty, postdoctoral fellows, and graduate students in support of today's research for tomorrow's cures.

Posted On 4/18/2013 - Archived On 9/29/2015

Pharmacology Publishes!

Just a sampling of our recent publications:

Post-translational Modification by an Isolevuglandin Diminishes Activity of the Mitochondrial Cytochrome P450 27A1. Casey D. Charvet, James Laird, Yunfeng Xu, Robert G. Salomon, and Irina A. Pikuleva. J Lipid Res. (2013) In Press.

  

Calcium Mobilization And Protein Kinase C Activation Downstream Of Protease Activated Receptor 4 (PAR4) Is Negatively Regulated By PAR3 In Mouse Platelets. Arachiche A, de la Fuente M, Nieman MT. PLoS One. 2013;8(2):e55740. Epub 2013 Feb 6.

Asymmetry of the rhodopsin dimer in complex with transducin. Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K. FASEB J. 2013 Jan 9. [Epub ahead of print]

Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K. J Clin Invest. 2013 Jan 2;123(1):121-37.

Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Ahmad MF, Wan Q, Jha S, Motea E, Berdis A, Dealwis C. Mol Cancer Ther. 2012 Oct;11(10):2077-86.

Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. Yuan Y, Kadiyala CS, Ching TT, Hakimi P, Saha S, Xu H, Yuan C, Mullangi V, Wang L, Fivenson E, Hanson RW, Ewing R, Hsu AL, Miyagi M, Feng Z. J Biol Chem. 2012 Sep 7;287(37):31414-26.

Inflammatory priming predisposes mice to age-related retinal degeneration. Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K. J Clin Invest. 2012 Aug 1;122(8):2989-3001.

Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis. Omarova S, Charvet CD, Reem RE, Mast N, Zheng W, Huang S, Peachey NS, Pikuleva IA. J Clin Invest. 2012 Aug 1;122(8):3012-23.

Coupling cellular localization and function of checkpoint kinase 1 (Chk1) in checkpoints and cell viability. Wang J, Han X, Feng X, Wang Z, Zhang Y. J Biol Chem. 2012 Jul 20;287(30):25501-9.

Posted On 3/12/2013 - Archived On 5/11/2013

Goutham Narla, our newest MTTP trainer was featured in The Daily

A team of researchers, led by Goutham Narla at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center and collaborators at the Mount Sinai School of Medicine and Erasmus Medical Center, has discovered a gene variant that drives the spread of breast cancer. Published in Scientific Translational Medicine, the study lays the early foundation for predicting which breast-cancer patients may develop more aggressive forms of the disease and for designing more effective treatments. For more info go to the Jan. 28 edition of http://thedaily.case.edu/news/
Posted On 1/30/2013 - Archived On 3/30/2013

The work of the Stewart lab is the Focus of the Biomedical Picture of the Day!

Click here or copy and paste to see their accomplishments: http://bpod.mrc.ac.uk/archive/2012/12/14
Posted On 12/14/2012 - Archived On 1/31/2013

Welcome to our newest Ph.D.s

Molly Taylor and Chris Ryder both received their Ph.D. degrees this November. Molly successfully defended her thesis entitled: The Role of Extracellular Matrix Rigidity and Altered microRNA Expression in TGF-beta-mediated Breast Cancer Progression. Chris' thesis was entitled:Effects of Acidosis on Survival Pathways in Lymphoid Malignancies. Congratulations and best of luck to them both!
Posted On 11/29/2012 - Archived On 2/28/2013

Marvin Nieman Receives Award!

Marvin Nieman was recently awarded from the Gilead Sciences Research Scholars Program in Cardiovascular Disease. Recipients of this competitive award are selected by a committee of scholars. The program is designed to support innovative scientific research in the filed of cardiovascular diseases.
Posted On 11/25/2012 - Archived On 1/25/2013

Congratulations to Amy Wilson-Delfosse!

Amy Wilson-Delfosse recently accepted the Robert J. Glaser Distinguished Teacher Award during the Association of American Medical Colleges annual meeting in San Francisco. Presented annually at the Awards dinner of the Association of American Medical Colleges (AAMC) by the President of Alpha Omega Alpha , this award recognizes outstanding contributions to the education of medical student by four faculty at LCME-approved schools of medicine.
Posted On 11/25/2012 - Archived On 1/25/2013

Pharmacology Retreat 2012

The Departmental Retreat is on November 15th and 16th at Kalahari Resorts in Sandusky, Ohio. See the program HERE.
Posted On 10/16/2012 - Archived On 11/15/2012

Mike Maguire Recognized for Excellence in Teaching

Ten CWRU faculty were recently recognized for their excellence in undergraduate teaching by Sigma Psi Sorority and Delta Upsilon Fraternity of CWRU at a luncheon in Thwing Student Center. Dr. Michael Maguire of the Department of Pharmacology was one of the honorees and the only faculty member from the School of Medicine recognized for undergraduate teaching.
Posted On 10/9/2012 - Archived On 1/20/2013

Dr. Andreas Engel Awarded Honorary Doctorate

Aarhus University in Denmark recently awarded Dr. Andreas Engel, Professor of Pharmacology, the Honorary Doctorate in Health Sciences. Andreas Engel has made a great contributions to the elucidation of the structure of human aquaporin-1 and the development of methods for 2-D and 3-D structure determination. LINK
Posted On 10/2/2012 - Archived On 11/1/2012

Science Publication!

Congratulations to Justin Flatt (Stewart Lab) who recently co-authored a paper in Science! The title of the paper is "Coagulation factor X activates innate immunity to human species C adenovirus". They used cryoEM and computational methods to model the adenovirus/host factor X interaction and from the analysis introduced a mutation that abrogated formation of the complex. With collaborators, they showed that coagulation factor X activates innate immunity to human adenovirus.
Posted On 9/27/2012 - Archived On 10/27/2012

Graduate Program Applications - Open!

Interested in a career in research? The Molecular Therapeutics Training Program is now accepting applications: Apply Here
Posted On 9/11/2012 - Archived On 10/11/2012

Casey Charvet publishes in JCI

Casey Charvet, a Ph.D. student in Irina Pikuleva's lab recently co-authored a paper entitled "Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis". This was published in the Journal of Clinical Investigation and shows a link between age-related macular degeneration and retinal cholesterol maintenance.
Posted On 8/7/2012 - Archived On 9/6/2012

MSTP student, Chris Ryder publishes in JBC!

Congratulations to Chris Ryder (Distelhorst Lab/MSTP student)who recently published in JBC. Chris's paper is entitled "Acidosis Promotes Bcl-2 Family Mediated Evasion of Apoptosis: Involvement of Acid-Sensing G Protein-Coupled Receptor GPR65 Signaling to MEK/ERK" and helps solve important issues surrounding tumor acidosis.
Posted On 7/17/2012 - Archived On 8/16/2012

Casey wins VSTP award!

Casey Charvet (Pikuleva Lab) is the winner of this year’s VSRC Symposium poster/presentation contest! The title of his presenation was "CYP27A1 Activity is Impaired by Post-Translational Modification: Implications for Retinal disease.". Great job, Casey!
Posted On 6/25/2012 - Archived On 7/25/2012

A successful defense!

Sanath Wijerathna had a successful public defense entitled "Structural and Biochemical Studies of Ribonucleotide Reductase Inhibition by dATP and Sml1." Sanath is leaving the Dealwis lab to teach and we wish him the best of luck!
Posted On 6/25/2012 - Archived On 7/25/2012

Debarshi publishes in The Journal of Clinical Investigation

Debarshi Mustafi (Palczewski lab) in collaboration with Dr. Tadao Maeda’s lab in the Department of Ophthalmology & Visual Sciences had their recent work accepted for publication by The Journal of Clinical Investigation detailing how inflammatory priming predisposes to age-related retina degeneration in certain genetic background populations.
Posted On 6/11/2012 - Archived On 7/11/2012

A successful defense!

Congratulations to Wannarasmi Ketchart who recently defended her dissertation "HEXIM1 as a therapeutic target in hormone resistant and metastatic breast cancer". We wish Nui the best of luck in her continued research!
Posted On 6/5/2012 - Archived On 7/5/2012

Justin Flatt wins at the Microscope Society Meeting of Northeast Ohio

Justin Flatt (Stewart lab) won the best student presentation award at the Microscope Society Meeting of Northeast Ohio. The Fifty-Sixth Annual May Conference was jointly sponsored by the Cleveland Sections of the Society for Applied Spectroscopy, the American Chemical Society – Analytical Topics Group, the Ohio chapter of the American Vacuum Society, and the Microscopy Society of Northeast Ohio. It was held at John Carroll University.
Posted On 5/25/2012 - Archived On 6/24/2012

Chris Ryder wins at Medicine Research Day!

Congratulations to Chris Ryder who brought home a poster prize at the Department of Medicine Research Day with his poster entitled "Acidosis Promotes Bcl-2 Family-Mediated Evasion of Apoptosis Via Activation of Acid-Sensing GPR65." Job well done!
Posted On 5/18/2012 - Archived On 6/17/2012

Art of Science Winner!

Ning Zhang, Postdoc in the Palczewski lab, recently won the Art of Science prize with her impressive GFAP stain of retinal muller cells. Great image!
Posted On 5/18/2012 - Archived On 6/17/2012

BGSS Awards!

Congratulations to Amanda Vreeland who won a poster presentation award and to Molly Taylor who won the oral presentation award at the 35th Annual Biomedical Graduate Student Symposium on May 9th.
Posted On 5/10/2012 - Archived On 6/9/2012

A Recognition of Outstanding Scholarship in Biomedical Sciences!

Two outstanding Postdoctoral fellows in the department have been recently awarded in recognition of their excellent Ph.D. research and scholarship. Dr. Gina Bernardo (Keri Lab) received the Doctoral Excellence Award in Pharmacology and Dr. Daniel Berry (Noy Lab) received the Doctoral Excellence Award in Nutrition. Congratulations to them both!
Posted On 5/4/2012 - Archived On 6/3/2012

Molly Taylor wins GSS Poster Award

The 2012 GSS Graduate Research Symposium showcased exceptional and diverse work being conducted by graduate students at Case Western. Molly Taylor's (Schiemann Lab) poster stood out from the crowd, though! Her poster entitled "The Role of MicroRNA181A in TGF-B-mediated Breast Cancer Progression presented" won top honors and is an excellent representation of her accomplishments in the Department of Pharmacology.
Posted On 4/11/2012 - Archived On 5/11/2012

Former SURP student publishes!

Congrats to Corbett Berry, a former SURP student, for publication of his first research article in Neural Development in collaboration with Michael Sceniak: "Facilitation of Neocortical Presynaptic Terminal Development by NMDA Receptor Activation" Sceniak MP, Berry CT and Sabo SL Neural Development 2012, 7:8 (16 February 2012)
Posted On 2/22/2012 - Archived On 4/20/2012

Chris Ryder shines at Lepow Medical Student Research Day

Congratulations to Chris Ryder who was recently awarded a prize for his poster at Lepow Day. Lepow Day is an opportunity for medical students to display their reserach done in their MD or Dual Degree programs. Chris's poster was entitled "Acidosis Promotes Bcl-2 Family-Mediated Evasion of Apoptosis Via Activation of Acid-Sensing GPR65" and covers his research in the Distelhorst lab.
Posted On 2/21/2012 - Archived On 3/22/2012

Debarshi representing MSTP in Colorado

Debarshi Mustafi (Palczewski Lab) was recently chosen to represent the Case Western Reserve University MD/Ph.D. program at the National MD/Ph.D. Conference in Keystone, Colorado. Not only was he chosen as a representative, but he received an award to pay his travel expenses. Debarshi is an excellent representation for both the MSTP program and the Department of Pharmacology.
Posted On 12/21/2011 - Archived On 2/20/2012

Find out more about the Molecular Therapeutics Training Program!

According the NRC rankings, Case Western's Pharmacology program ranks in the top tier for both top scholarship and top-notch programs. For more information about our graduate program Click Here
Posted On 12/19/2011 - Archived On 3/18/2012

Interested in a Summer Research Program?

The Department of Pharmacology is currently accepting applications for the summer of 2012. Students are paired with faculty members and given opportunitites to study and learn from a variety of research topics. Click here for more information.
Posted On 12/7/2011 - Archived On 2/6/2012

Top Student and Top PostDoc Awards

Congratulations to our annual awardees. The 2011 Outstanding Graduate Student Award went to Debarshi Mustafi (Palczewski Lab) and the 2011 Outstanding Postdoctoral Fellow Award was presented to Glenn Lobo, Ph.D., (von Lintig Lab). In addition, Luke Bury won the Greenfield Travel Award. Wonderful job!
Posted On 11/14/2011 - Archived On 12/14/2011

Top Presentations!

At the 2011 Pharmacology Retreat held at the Kalahari Resorts, we had many top presentations. This years award winners, selected by a panel of judges were Meghana Gupta (Oral Presentation) and Amar Desai (Poster Presentation). Both students had wonderful presentations at a very competative retreat!
Posted On 11/14/2011 - Archived On 12/14/2011

A new discovery based on nematode Parkinson's disease models.

Congratulations to an interesting new publication from the Feng Lab in Journal of Neuroscience Methods. This work opens the door to high throughput chemical and genetic screening based on C. elegans neuromotor activity. Zheng, M., Gorlenkova, O., Yang, J. and Feng, Z. A liquid phase based C. elegans behavioral analysis system identifies motor activity loss in a nematode Parkinson's disease model.
Posted On 11/9/2011 - Archived On 11/16/2011

Undergraduate Poster Competition Results

Congratulations to Tenia Harris from Cleveland State University who's poster "Measuring Human Photosynthesis: Determiniation of 25-hydroxyvitamin" won the Pharmacology Undergraduate Research Poster Competition. There were also three runner-ups, Charles Fulco (CWRU), Yenan Zhu (CWRU), Carolina Parada (CSU). Overall, everyone did an excellent job and had impressive research posters.
Posted On 11/7/2011 - Archived On 12/7/2011

CCMSB featured in the Plain Dealer

The Plain Dealer picked up on the Cleveland Foundation's support of the Center for Membrane and Structural Biology at CWRU. The Cleveland Foundation provided a grant that is being used to hire top-notch researchers and buy equipment, thus boosting the region's efforts to become top tier bio-tech center. See the article HERE
Posted On 9/27/2011 - Archived On 10/27/2011

Distinguished Award

Dr. Kris Palczewski, John H. Hord Professor and Chair Department of Pharmacology recently received the Knight's Cross of the Order of Merit of the Republic of Poland (Krzyz Kawalerski Orderu Zaslugi Rzeczpospolitej Polskiej). The order is awarded to foreigners or Poles resident abroad for distinguished contribution to international cooperation or cooperation between Poland and other countries. It is awarded by the President of Poland.
Posted On 9/22/2011 - Archived On 10/22/2011

Retreat Information 2011 is online

This year the Department of Pharmacology is pleased to announce that our annual retreat will be held at the Kalahari Resort in Sandusky Ohio on November 10 and 11. Further information is now available online HERE and deparmental members are encouraged to register online.
Posted On 9/14/2011 - Archived On 10/14/2011

Debarshi has a hot news topic!

Debarshi Mustafi's (Palczewski Lab) recent work on retinal degeneration has been a hit on the scientific news sites. It was picked up by over 75 news sources, including Cell Press. Debarshi's findings regarding Enhanced S-Cone Syndrome help further undrestand the visual cycle. See the Case Western Reserve University article HERE
Posted On 9/7/2011 - Archived On 10/7/2011

Summer Undergraduate Research Opportunities

Applications are now being accepted for the summer of 2012, Summer Undergraduate Research Program (SURP). Undergraduates interested in expanding their research experience are encouraged to apply. Apply Here
Posted On 9/1/2011 - Archived On 11/14/2011

Undergraduate Poster Competition Announced

The Department of Pharmacology is sponsoring an Undergraduate Research Poster Competition. This is hopen to all undergraduates, at Case Western Reserve and elsewhere. Abstracts are due on October 15th. More info - contact cami@case.edu
Posted On 8/30/2011 - Archived On 9/29/2011

A collabrative work of John Feng was accepted by Cell.

Congratulations to Dr. John Feng for his recent paper in Cell. Mapping the neural circuits that promote motor initiation in freely-behaving C. elegans. Beverly J. Piggott*, Jie Liu*, Zhaoyang Feng*, Seth A. Wescott, and X. Z. Shawn Xu
Posted On 8/30/2011 - Archived On 9/29/2011

Gina Graduates!

Congratulations, Gina Bernardo! Her Final Dissertation Defense for the Ph.D. was held on Friday, August 12th and was entitled "Discerning the Role of FOXA1 in Mammary Gland Development and Breast Cancer". Gina joined Ruth Keri's lab in 2006 and has been on a role with several publications, honors, teaching services and attended several meetings. We wish her continued success!
Posted On 8/15/2011 - Archived On 9/14/2011

Tonibelle and Gina will attend the NGRSC

Tonibelle Gatbonton-Schwager and Gina Bernardo were recently selected to attend the NIH Graduate Student Rsearch Conference in October. Tonibelle will present a poster about her work in the Letterio and Tochtrop Labs and Gina will present on the Keri lab work she's done. Good job!
Posted On 8/15/2011 - Archived On 9/14/2011

Jennifer Yori publishes in Neoplasia

Congratulations on an excellent article! Jennifer Yori's paper published in Neoplasia in the July issue. The title of her publication is: Krüppel-like factor 4 Inhibits Tumorigenic Progression and Metastasis in a Mouse Model of Breast Cancer. Good job!
Posted On 7/19/2011 - Archived On 8/18/2011

Save the Date: Annual Pharm Retreat

This year the Pharmacology Retreat will be held on Thursday and Friday, November 10 and 11 at Kalahari Resort and Convention Center in Sandusky, OH. More details to follow.
Posted On 7/19/2011 - Archived On 8/18/2011

Another new publication from the Feng Lab

The Feng lab has another manuscript accepted by PLoS ONE. In this paper, they described the novel functional relationship between LRRK2, a Parkinson's Disease related kinase, and endoplasmic reticulum stress in dopaminergic neuron degeneration. Dr. Yiyuan Yuan is the first author of this story titled "Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans"
Posted On 6/27/2011 - Archived On 7/27/2011

Debarshi publishes!

Debarshi Mustafi's recent paper is the first use of RNA-Sequencing technology in the murine eye and retina and in combination with structural analysis revealed the cause of retinal degeneration in ESCS disease. It's entitled "Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration." and was recently published in FASEB Journal.
Posted On 6/10/2011 - Archived On 7/10/2011

Andrea and Amar win BGSS Awards!

We'd like to congratulate Andrea and Amar on their recent BGSS Awards. Andrea Boyd-Tressler (Dubyak Lab): "The Gating of Pannexin 1-Mediated ATP Release Channels by Mechanical Stress Stimuli," received the Vance Lemmon Award Amar Desai(Gerson Lab): "The Role of Exo1 in DNA Mismatch and Double Strand Break Repair: Implications for Improved Radiotherapy in Cancer" received the Marcus Singer award.
Posted On 5/9/2011 - Archived On 7/8/2011

Ruth Keri named Associate Director at the Case Comprehensive Cancer Center

After a national search, Ruth Keri, associate professor in the departments of pharmacology, genetics and oncology, has been named associate director for basic research at the Case Comprehensive Cancer Center. Her interest in the effects of reproductive hormones led to her long-standing interest in breast cancer, and a more recent interest in human breast cancer. She serves on a number of NIH and DOD scientific review panels, has been identified as a key investigator in breast cancer and is recognized as a top educator in the department of pharmacology.
Posted On 4/8/2011 - Archived On 7/8/2011

W331 is now the Webster Conference Room!

The Conference Room (W331) was recently dedicated to Les Webster, spirit leader of the Community of Pharmacology for nearly four decades. Dr. Webster has been a leader in deed and example, promoting the scientific, intellectual, and personal development of faculty, students, and staff at all career levels. His legacy will have a lasting impact on the Department of Pharmacology, the School of Medicine, and Case Western Reserve University.

Posted On 4/1/2011 - Archived On 5/1/2011

Molly Taylor's Featured Article

Molly Taylor has been publishing up a storm! Her recently submitted article in Neoplasia "Lysyl Oxidase Contributes to Mechanotransduction-mediated Regulation of Transforming Growth Factor-b Signaling in Breast Cancer Cells" has been chosen as a featured article. She also has a co-authored paper in the Journal of Mammary Gland Biology and Neoplasia, which is running a special issue on the role of TGFbeta in mammary gland development and tumorigenesis.
Posted On 3/31/2011 - Archived On 4/30/2011

Debarshi's on a roll!

MD/Ph.D. student in the Palczewski lab, Debarshi Mustafi recently published in the Journal of Neuroscience Methods "K. Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology". In addition, he will be presenting this work at the Microscopy and Microanalysis Meeting in Nashville, TN in August, for which he was awarded with the 2011 Presidential Student Award by the Microscopy Society of America. This will be presented at the Opening Plenary session of the meeting and pay for all expenses. Great job, Debarshi!

Posted On 3/31/2011 - Archived On 4/30/2011

The Maguire and Dealwis labs have published in Structure.

X-ray Crystallography and Isothermal Titration Calorimetry Studies of the Salmonella Zinc Transporter ZntB
Qun Wan*, Md Faiz Ahmad*, James Fairman, Bonnie Gorzelle, Mariá de la Fuente, Chris Dealwis, and Michael E. Maguire
Structure (2011) in press.
*equal contribution
Posted On 3/2/2011 - Archived On 4/1/2011

Nature Publication!

Sanath Wijerathna and the Dealwis lab, publishes in Nature - Structural and Molecular Biology. His article is titled "Structural basis for allosteric regulation of human ribonucleotide" and covers how Ribonucleotide reductase (RR) is essential to maintain cellular pools of dNTPs, and its activity is controlled allosterically by ATP (activator) and dATP (inhibitor). Now crystal and EM structures of human and yeast RR1 in complex with different nucleotides, together with mutagenesis and functional analysis, reveal how dATP binding induces hexamerization and consequence inhibition of the enzyme. Nature.com
Posted On 2/21/2011 - Archived On 3/23/2011

Nui and the Montano lab publish in Oncogene

Research on breast cancer hormonal therapy conducted by four individuals in the Department of Pharmacology and the Case Comprehensive Cancer Center at the School of Medicine will be published in the journal Oncogene. Graduate student Wannarasmi Ketchart, the first author, along with senior authors Monica Montano, John Pink and Jeffrey Albert, found a protein factor, HEXIM1, that proved to be a critical determinant of a person’s response to tamoxifen, a hormonal therapy used for breast cancer. Resistance to tamoxifen is common after five years, but their research found that a loss of HEXIM1 results in resistance to tamoxifen.
Posted On 2/18/2011 - Archived On 3/20/2011

RESEARCHERS MOISEENKOVA-BELL AND TESAR NAMED 2011 MT. SINAI HEALTH CARE FOUNDATION SCHOLARS

Vera Moiseenkova-Bell, PhD, assistant professor in the Department of Pharmacology, has been named as one of the Mt. Sinai Health Care Foundation Scholars for 2011. The Mt. Sinai Scholars program is intended to fund the research endeavors of bright and promising young investigators, helping to attract talented researchers to the School’s basic science departments and providing funds to bolster the startup and early development of their independent laboratories. Dr. Moiseenkova-Bell is studying the mechanisms that contribute to pain and temperature sensation. The objective of her research is to unravel the structural basis for how pain signals are relayed throughout the body in order to develop novel analgesic agents.
Posted On 1/11/2011 - Archived On 3/10/2011

Recent Dissertation Defenses!

Congratulations to Jennifer Yori (Keri lab) who recently defended her defense "Discerning the Role of KLF4 in Breast Cancer" and Andrea Moomaw (Maguire lab) who defended "Structure-Function Studies of the CorA Magnesium Channel". We wish them both luck in their research careers!
Posted On 1/5/2011 - Archived On 2/4/2011

Palczewski Lab's Plentiful Publications!

December was a great month for the Palczewski lab, working in conjuction with Irina Pikuleva and Masaru Miyagi labs. They had two publications that came through. 1) Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. J Biol Chem. 2010 Dec 15. [Epub ahead of print]PMID: 21159775 [PubMed - as supplied by publisher]Free ArticleRelated citations 2.Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange.Lodowski DT, Palczewski K, Miyagi M. Biochemistry. 2010 Nov 9;49(44):9425-7. Epub 2010 Oct 15.PMID: 20939497 [PubMed - in process]Related citations
Posted On 1/5/2011 - Archived On 2/4/2011

Andrea gets a FASEB MARC/ASPET travel award!

Andrea Boyd-Tressler from the Dubyak lab recently received a FASEB MARC/ASPET travel award to go to Experimental Biology Meeting in DC April 9-13th. This multidisciplinary, scientific meeting features plenary and award lectures, pre-meeting workshops, oral and posters sessions, on-site career services and exhibits of an array of equipment, supplies and publications required for research labs and experimental study. Congratulations, Andrea!
Posted On 1/5/2011 - Archived On 2/4/2011

$10 Million to Study Retinal Disease

The Departments of Pharmacology and Ophthalmology and Visual Sciences at Case Western Reserve University School of Medicine have been awarded a $10.1 million grant from the National Eye Institute (NEI) to research and develop new treatments for diseases of the retina, a leading cause of blindness. More information
Posted On 1/5/2011 - Archived On 2/4/2011

Interested in applying to graduate school?

The Department of Pharmacology at Case Western Reserve Unviversity is a top ten gradudate program. Apply Here
Posted On 12/2/2010 - Archived On 2/1/2011

2010 Retreat Pictures

A few of the pictures from the 2010 Retreat are available here. Additional high resolution pictures are on the file server "S" drive, S:\Retreat\Retreat 2010

Posted On 11/23/2010 - Archived On 12/23/2010

Retreat Awards!

Congratulations to Chris Ryder who won for the best oral presentation and Yarolslav Tsybovsky won the best poster presentation. Great job guys!
Posted On 11/22/2010 - Archived On 12/22/2010

Departmental Award Winners!

The Department of Pharmacology has an amazing array of excellent researchers. This year we recognized Gina Bernardo with our Outstanding Student award, David Lodowski with our Outstanding Postdoc award, and both Amar Desai and Debarshi Mustafi won the Greenfield Travel award.
Posted On 11/22/2010 - Archived On 12/22/2010

Nature Publication!

Grazyna Palczewska and her colleagues in the Department of Pharmacology use the noninvasive imaging modality of two-photon microscropy to study the retinoid cycle in the mammalian eye at the subcellular level. This may prove useful in assessing retinal changes in the human eye at the earliest stage and long before retinal diseases become apparent and result in loss of vision. See publication Here

Posted On 11/16/2010 - Archived On 12/16/2010

Retreat Program 2010

The Pharmacology Retreat Program is available online: Program
Posted On 11/15/2010 - Archived On 12/15/2010

Reema tackles Prostate Cancer!

Reema Wahdan-Alaswad recently published in Cancer Research. Her paper entitled, "Insulin-Like Growth Factor I Suppresses Bone Morphogenetic Protein Signaling in Prostate Cancer Cells by Activating mTOR Signaling." is now available online. Abstract Link

Posted On 11/15/2010 - Archived On 12/15/2010

Luke Bury knows his Synapses!

Graduate student, Luke Bury (Shasta Sabo lab) recently published his first article in Molecular Intervention. His article, "How it's made: The Synapse" which relays how a synapse is formed in the central nervous system. Good job, Luke!

Posted On 10/20/2010 - Archived On 11/19/2010

Save the Date: Holiday Party

December 8th, 2010 (Wednesday) 6:30pm Windows on the River

Posted On 9/30/2010 - Archived On 10/30/2010

Interested in finding more about our graduate program?

The Molecular Therapeutics Training Program (MTTP) is a top 10 Pharmacology doctoral training program. With a legacy of three Nobel Laureates and a growing faculty body, the department offers the foundation for a career in pharmacological research. For more information: MTTP Information
Posted On 9/30/2010 - Archived On 10/30/2010

2010 Retreat

The annual Retreat at Geneva on the Lake is on November 18^th and 19^th
Retreat Information
Retreat Brochure
Posted On 8/26/2010 - Archived On 10/13/2010

Undergrads present their posters!

The Department of Pharmacology's Summer Undergraduate Research Students all presented their posters on July 29th. Students came from across the country and represented schools such as Johns Hopkins and Notre Dame. The presentations were excellent and showed the hard-work that they've all put in during the 10 week program.

Posted On 8/4/2010 - Archived On 9/3/2010

Grand Prize Winner!

Gina Bernardo was the grand prize winner in the 2010 Art of Science Competition sponsored by the Office of Graduate Education with her image titled “Mammaries in Bloom”.

Posted On 8/2/2010 - Archived On 9/1/2010

New Students!

The Department of Pharmacology would like to welcome the entering MTTP class. This year we have Olga Gorelenkova, Milos Beljin and Sharon Rymut starting rotations this summer.
Posted On 7/7/2010 - Archived On 8/6/2010

Summer Undergraduate Students - Doing Great!

Mark your calendars: July 29th is the final poster presentation for our Summer Undergraduate Research Student Program participants. This year we have 12 students associated with our program who were picked out of a highly competitive applicant pool and placed in pharmacology labs. They've been doing great and we're excited to see their research at the end of the program!
Posted On 6/29/2010 - Archived On 7/29/2010

Gina Bernardo's Research on the Cover of Development

Gina Bernardo from the Ruth Keri lab is one of the authors who identified that FOXA1 is required for formation of mouse mammary terminal end buds (depicted in cover image). These structures are necessary for pubertal development of the mammary gland. Failed development of terminal end buds in FOXA1 null glands is due, at least in part, to the concomitant loss of Estrogen Receptor-alpha. This important work is featured on the cover page of Development. We congratulate Gina on her contribution to understanding FOXA1's importance in mammary gland development.

Posted On 5/27/2010 - Archived On 6/26/2010

Graduate Symposium!

The Department of Pharmacology was well represented at the 2010 Graduate Student Symposium. Gina Bernardo (Keri Lab) got 1st place oral presentation. Other award winners were Amar Desai (Gerson Lab), Elizabeth Sabens (Mieyal Lab), Reema Wahdan-Alaswad (Danielpour Lab).
Posted On 5/7/2010 - Archived On 6/6/2010

Research Symposium Awards!

Elizabeth Sabens received a third place award for her poster entitled "Levodopa Drug-Induced Apoptosis of Model Neurons through Alteration in Thiol Homeostasis: Implications in the Treatment of Parkinson's Disease" and Reema Wahdan received an Honorable Mention with her poster entitled "Insulin-like Growth Factor-I Suppresses Bone Morphogenetic Protein Signaling through a Phosphatidylinositol 3-Kinase, Akt and mTOR-Dependant Mechanism". We are proud of our graduate student's representing the excellent work that's being done in our department.

Posted On 5/7/2010 - Archived On 6/6/2010

Dr. Jason Mears joins the Faculty

Dr. Mears will join the faculty of the Department of Pharmacology as an assistant professor this summer. Read more about Dr. Mears and his research.
Posted On 5/4/2010 - Archived On 7/3/2010

Dean's Scientific Research Symposium Information

The Dean's Scientific Research Symposium is now available online. The Dean’s Symposium, hosted by the Center of Membrane and Structural Biology at the Case Western Reserve University in Cleveland, brings together the Nobel Laureate Peter Agre and six outstanding internationally renowned structural biologists striving to understand the function of biomolecular machines in the context of the entire organism.
Posted On 4/22/2010 - Archived On 5/22/2010

Another Inamori Mentoring Award

The Pharmacology Department would like to congratulate Dr. Robert Bonomo, a secondary faculty member, on receiving this year's Inamori Mentoring Award. This award is given to an outstanding mentor who has passed on wisdom and given insightful guidance to their students.
Posted On 4/21/2010 - Archived On 5/21/2010

Impressive In Press!

Congratulations to graduate student, Gina Bernardo on her recent submission. "FOXA1 is an essential determinant of ERα expression and mammary ductal morphogenesis." is being published in Development.

Posted On 4/20/2010 - Archived On 5/20/2010

Great work!

Jen Yori, a graduate student in the Keri lab just published a paper in J. Biol. Chem. entitled Kruppel-like factor 4 (KLF4) inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression. Great work!

Posted On 4/9/2010 - Archived On 5/9/2010

Off to Italy!

Congratulations Elizabeth Sabens for receiving a NSF-sponsored travel award. Elizabeth will be presenting a poster at the Gordon Research Conference in Lucca, Italy on the topic of Thiol-Based Redox Regulation and Signaling. We wish Elizabeth happy travels and a wonderful conference experience.
Posted On 4/5/2010 - Archived On 5/5/2010

Philip Kiser receives the Doctoral Excellence Award

The Doctoral Excellence Award was established to recognize exceptional research and scholarship in PhD programs at the School of Medicine. Nominees' work is highly original and represents a significant contribution to the field. Nominees were reviewed and recipients selected by a subcommittee of the Graduate Program Directors. We congratulate Philip on this selective award!
Posted On 3/23/2010 - Archived On 4/22/2010

The Winning Potato!

The 2nd Annual, St. Paddy's Day Potato Dress-Up was a success! Each team answered trivia that led to them being able to dress up their potato. After much deliberation, the winning potato was a Pirate them, carefully created by the Chris Ryder, Tonibelle Gatbonton, and Reema Wahdan-Alaswad Team. Congratulations!
Posted On 3/19/2010 - Archived On 4/18/2010

A New PhD!

Congratulations Philip Kiser, on his excellent dissertation entitled “Structural and Biochemical Studies of RPE65, the Retinoid Isomerase of the Visual Cycle”. Philip is graduating from the Palczewski lab with 12 submitted publications and several accolades such as Student of the Year and the Excellence in Research Award. The Department wishes Philip all the best in his continued research.

Posted On 3/19/2010 - Archived On 4/18/2010

Save the date:

Dean's Electron Microscopy Scientific Symposium, Wednesday, May 19th in Strosaker Auditorium. Featured speakers include Peter Agre, Joachim Frank, Tamir Gonen, Irina Serysheva, Andrej Sali, Robert Stroud, and J. Richard McIntosh.
Posted On 2/17/2010 - Archived On 5/19/2010

A Successful CCMSB Open House!

The Cleveland Center for Membrane and Structural Biology facility is now open. The recent open house showcased the new facility, exciting new pieces of equipment and a future full of opportunities.

Posted On 2/5/2010 - Archived On 3/27/2010

You-Wei Zhang's Lab Publishes in Cell Cycle

Congratulations to the Zhang lab for their recent publication entitled "Targeting the checkpoint kinase Chk1 in cancer therapy." Their work on replication checkpoints helps understand cellular sensitivity to cancer therapies.

 

Posted On 2/5/2010 - Archived On 3/18/2010

Feng Lab's second publication since joining!

A research article titled "Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans" from John Feng's lab will be published at PLoS ONE. This is the second paper produced by John Feng's lab at our department and we are excited about their continued research.
Posted On 2/5/2010 - Archived On 3/18/2010

Great job, Kevin!

Kevin Tai-Pang Eng recently defended his dissertation, Non-natural Nucleotides as Modulators of ATPases. His work in the Berdis lab these last few years has given him excellent work that we hope will springboard him to a very successful scientific career. Best of luck, Kevin.

Posted On 1/19/2010 - Archived On 2/18/2010

Excellent Defense!

Congratulations to Dagmar Hajkova-Leary on her successful defense: Are we Still in the Dark? Proteomic Studies to Elucidate Mechanism of Light Induced Photoreceptor Cell Apoptosis. We wish her the best in her continued research.

Posted On 12/8/2009 - Archived On 2/7/2010

Ruth Keri receives 2009 Pilot Project Grant

Ruth Keri, PhD, Pharmacology, with her project entitled “Identification of biomarkers of bone marrow micrometastases in HER2 positive breast cancer” was awarded a pilot project grant. She was one of eleven researchers who received pilot awards totaling $671,569 from the CTSC to fund studies in translational science and early clinical studies.
Posted On 12/1/2009 - Archived On 2/1/2010

Best of luck, Rod!

Rod Nibbe defended his dissertation "Systems Biology of Human Colorectal Cancer" with distinction. Graduating in under 5 years, we're proud of his accomplishments and we wish him the best in his research back home in Alaska!

Posted On 12/1/2009 - Archived On 2/1/2010

Retreat Awards!

Congratulations to Glenn Lobo for best oral presentation and Reema Wahdan-Alaswad for best poster presentation. In addition, the top student award goes to Philip Kiser, top postdoc is Marcin Golczak, and Chris Ryder received the Greenfield Travel Award. Good job everyone!
Posted On 11/23/2009 - Archived On 12/23/2009

Updated website

Welcome to the relaunch of the Pharmacology web site! If your browser is Internet Explorer, please use IE7 or above for the best experience. Report any problems to Barry Lukoff.
Posted On 11/8/2009 - Archived On 12/8/2009

Ruth Keri speaks at the next Science Cafe

Due to a fire at Great Lakes Brewery, Ruth Keri's Science Cafe discussion is postponedMore Info

Posted On 11/5/2009 - Archived On 11/9/2009

PHRM 432 now taught by Paul Park

PHRM 432 - Current topics in vision research is now covering a broad range of current topics in vision research.  For more information contact paul.park@case.edu or see the course catalogue online. 
Posted On 10/22/2009 - Archived On 12/21/2009

Marjorie Montanez-Wiscovich, Ph.D.

Congratulations to Marjorie Montanez-Wiscovich who successfully defended her dissertation entitled Discerning the role of LMO4 as a global modulator of G2/M cell cycle progression and centrosome cycle in breast cancer cells.  We wish her the best of luck as she continues her studies with her MD next on the list! 
Posted On 10/22/2009 - Archived On 11/21/2009

Proteomics Course Syllabus (PHRM 555)

The course will be offered for graduate students in the coming spring semester. The Syllabus can be downloaded here.
Posted On 9/14/2009 - Archived On 12/31/2009

Congratulations!

Reema Wahdan-Alaswad recently was granted a National Reserach Service Award through the NIH.  This three year grant will support her studies on mTOR and BMP in prostate cancer.  Good job, Reema! 
Posted On 9/11/2009 - Archived On 10/11/2009

2009 Retreat

The annual Retreat at Geneva on the Lake is on November 19^th and 20^th
Retreat Information
Posted On 9/1/2009 - Archived On 11/20/2009

Molecular Cell article!

Congratulations to You-Wei Zhang and his recently published article "The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress" in Molecular Cell.  This study helps understand tumor cell resistance in certain anticancer drugs and is Dr. Zhang's first published paper here in the Department of Pharmacology. 

Posted On 8/17/2009 - Archived On 9/16/2009

Summer Undergraduate Students complete their research

The final poster session for the Summer Undergraduate Research Program (SURP) showed the cumulative efforts of the departments 8 student researchers.  With topics ranging from anti-obesity activities of palmitoleate to zebra fish models, the students presented some interesting findings.  We wish them all on in their continued studies. 
Posted On 8/10/2009 - Archived On 9/9/2009

In memoriam...

Mona Sternlicht, long-time member of the Pharmacology Community has died.  Mona's quiet confidence was the stabilizing force of the Sternlicht laboratory, and her genteel nature was an inspiration to all of us.  Visitation and Service Information.
Posted On 8/6/2009 - Archived On 9/5/2009

A successful defense!

Congratulations to Jose Gomez who rivited the crowd with his defense entitled "Development of Cell Pentrating Bax Inhibiting Peptides".  Jose has been an intrinsic member of the department and will be greatly missed! 
Posted On 8/6/2009 - Archived On 9/5/2009

A new leadership role!

To recognize Dr. Amy Wilson-Delfosse's contribution to the School of Medicine, Dr. Daniel Ornt and Dean Pam Davis appointed her as the Assistant Dean, for Basic Science Education.  Dr. Wilson-Defosse is an excellent representative from the Department of Pharmacology in both the School of Medicine curriculum, and coursework.  Congratulations, Amy.
Posted On 7/10/2009 - Archived On 8/9/2009

2,405 citations and counting...

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor is making headlines...or rather, footnotes.  It is currently ranked as the 5th most cited article in Biology and BioChemistry.  This paper was originally published by our very own chair, Dr. Palczewski in the August 4, 2000 issue of Science.  The heavy citations represent the groundbreaking work that Dr. Palczewski has accomplished in his career and we congratulate him on having such an influential publication. 
Posted On 7/9/2009 - Archived On 8/8/2009

Breakthrough by Bing Cheng Wang!

Not only was it featured in Cancer Cell, but Dr. BC Wang's recent work with EphA2 was written about enthusiastically in the Cleveland Plain Dealer LINK.  His paper "EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt" discusses brain tumor progression and it's relationship to the codependency of ephrin-A1 and EphA2. More...

Posted On 7/7/2009 - Archived On 8/6/2009

Fighting breast cancer - Steve Sizemore receives a DoD Postdoctoral Fellowship

As part of the 2008 Breast Cancer Research Program, Steve Sizemore was recently awarded a Postdoctoral Fellowship award for 3 years.  The title of his proposal was "FoxC1 in Basal-Type Breast Cancer".
Posted On 6/17/2009 - Archived On 7/17/2009

Research ShowCASE Award Winners!

Emhonta Johnson (Keri Lab) was one of four recipients of a post-doctoral research award for his outstanding poster presentation. The title of his poster was "ErbB2 activation of Rac1/Cdc42 requires p120ctn for induction of tumor cell migration/invasion".

Hany Sobhi (Hoppel Lab) also won a post-doctoral research award.  The title of his poster was titled “Synthesis and Characterization of Lipophilic Coenzyme A, Thioester Derivatives from Nonstandard Medium Chain Fatty Acids”

Reema Wahdan-Alaswad (Danielpour Lab) won 3rd place on her poster presentation.  The title of her poster was “Deregulation of BMP Signaling in Prostate Cancer”
Posted On 4/30/2009 - Archived On 6/30/2009

Dr. Taylor joins the faculty

Dr. Taylor will join the faculty as an Assistant Professor in August. Derek Taylor received his Ph.D. from the University of California, San Diego in 2003 where he was trained in molecular and structural virology in Dr. John (Jack) Johnson's laboratory. For his thesis work, Derek worked on non-enveloped RNA viruses as model systems for viral assembly, maturation, and infection.  The work concentrated specifically on characterizing a pH-dependent, maturational cleavage event, and in determining the atomic structure, using X-ray crystallography, of various viral capsids within the tetravirus family. In 2004, Dr. Taylor began an HHMI post-doctoral fellowship at the Wadsworth Center under the tutelage of Dr. Joachim Frank (now at Columbia University). During the fellowship, Derek used cryo-electron microscopy (cryo-EM) and single particle image reconstruction to visualize eukaryotic ribosomes, stalled at various physiological stages, at sub-nanometer resolution.  In 2008, Derek spent a year with Dr. Tom Cech at the University of Colorado at Boulder working on telomeric complex structure and assembly, which he continues to investigate.
Posted On 4/30/2009 - Archived On 6/30/2009

Dr. Moiseenkova-Bell joins the faculty

Dr. Moiseenkova-Bell will join the faculty at Case in the summer of 2009 as Assistant Professor of Pharmacology.  Dr. Moiseenkova-Bell graduate and postdoctoral training have been in membrane protein structure-functional analysis, with an emphasis on TRP (transient receptor potential) channels that play an important role in signal transduction pathways for pain and temperature sensation. She received her Ph.D. from the University of Texas Medical Branch at Galveston in 2004, where she worked in Dr. Burgess Christensen’s laboratory concentrating on the structural and functional analysis of temperature receptors in reptiles and mammals. During her training, she succeeded in the overexpression and purification of the TRP channels using the yeast strain Saccharomyces cerevisiae and showed that this method can produce pure TRPV1 channel suitable for structural work.  That same year, she joined Dr. Theodore Wensel’s laboratory at Baylor College of Medicine, where she continued her work on TRP channels structure determination and solved the first three-dimensional structure of the TRPV1 channel using cryo-electron microscopy and single particles reconstruction. Dr. Moiseenkova-Bell published research papers in journals such as PNAS, Journal of General Physiology, American Journal of Physiology, Biochemical and  Biophysical Research Communications.
Posted On 4/29/2009 - Archived On 6/29/2009

The Newest Board Member

Dr. Amy Wilson-Delfosse is the newest board member in the International Association of Medical Science Educators (IAMSE).  This is a three year term after Dr. Wilson-Delfosse's active involvement in the membership committee.  The IAMSE is founded on the guiding principle to contribute to the efforts of advancing medical education through faculty development and ensuring that the teaching and learning of medicine continues to be firmly grounded in the sciences.
Posted On 4/21/2009 - Archived On 5/21/2009

Outstanding Mentor in Our Midst!

Congratulations to Dr. John Mieyal who is the inaugural recipient of the Inamori Award for Excellence in Mentoring to be presented at this year's Reserach ShowCASE on April 16th at 3:00pm.  Dr. Mieyal was nominated for this award by Dr. Suparna Qanungo who submitted an essay describing Dr. Mieyal's compassionate, consistent and challenging mentoring style.  An outside reviewer judged this essay and Dr. Mieyal's amazing mentoring qualities to be worthy of recognition.  The Inamori International Center for Ethics and Excellence is committed to promoting ethical leadership and is pleased to recognize the positive impact that Dr. Mieyal has on his trainees.  The Department of Pharmacology has long recognized and appreciated Dr. Mieyal's role as a leader and mentor and joins in celebration for this well-deserved recognition!
Posted On 4/15/2009 - Archived On 5/15/2009

Cancer Progression and Metastasis

Congratulations to Melissa Shelton (Keri lab) who was recently awarded a 3 year post-doctoral fellowship by Department of Defense, Breast Cancer Research Program.  Her grant proposal focuses on cancer progression and metastasis
Posted On 3/26/2009 - Archived On 4/25/2009

Breast Cancer Chemoprevention

Congratulations to Nirmala Krishnamurthy (postdoctoral fellow in the laboratory of Dr. Monica Montano) who was just awarded a Department of Defense Postdoctoral Fellowship. Her grant proposal was scored in the outstanding range and will fund her project on breast cancer chemoprevention.
Posted On 3/25/2009 - Archived On 4/25/2009

2009 Sternlicht Memorial Lecture - Horwich

Dr. Arthur Horwich graciously presented for the 2009 Sternlicht Memorial Lectureship in memory of Robert and Hi Sternlicht.  His talk was entitled "Chaperone machines and involvement in a form of ALS". For more information about our special lectureships: http://pharm/calendar/special.aspx
Posted On 3/23/2009 - Archived On 4/22/2009

Dr. Bonomo elected to Association of American Physicians

Dr. Robert Bonomo (http://pharm/department/faculty/secondary/bonomo.aspx), a secondary faculty member in Pharmacology, was recently elected into the Association of American Physicians (http://aap-online.org/).  Annually, 60 individuals are nominated to join, after making significant contributions to the advancement of scientific and practical medicine.  This recognition is an honor and gives members further opportunity to share scientific goals and discoveries.  
Posted On 3/17/2009 - Archived On 4/16/2009

Irina Pikuleva receives the Jules & Doris Stein RPB Professorship Award

Dr. Irina Pikulava, a secondary faculty member in Pharmacology, was the only Research to Prevent Blindness Stein awardee in the United States this year.  This $650,000 grant was established to attract exceptionally talented basic scientists to devote their career to eye research.
Posted On 3/10/2009 - Archived On 4/9/2009

Xiaoxue Zhang Defense

The Department would like to congratulate Xiaoxue Zhang on successfully defending her thesis: 1,25-Dihydroxyvitamin D3-Induced Genes in Osteoblasts: Uncovering New Functions for Meningioma 1 and Semaphorin 3B in Skeletal Physiology.  Xiaoxue has great things ahead of her!
Posted On 2/19/2009 - Archived On 3/21/2009

Greg Tochtrop - A Glennan Fellow

We congratulate Greg Tochtrop, Assistant Professor of Chemistry and a secondary faculty member in Pharmacology on being recently awarded the Glennan Fellowship. This award reflects Dr. Tochtrop's exceptional promise and balance in both teaching and scholarship. This is an honor and a credit to his role in the development of a chemical biology curriculum at CWRU. News Article
Posted On 2/17/2009 - Archived On 3/17/2009

2008 Holiday Party

The Department of Pharmacology enjoyed a festive holiday party at the George S. Dively Center. Thanks to Drs. Ruth Siegel and Chris Dealwis for organizing this celebration. View pictures here …
Posted On 12/16/2008 - Archived On 2/15/2009

2008 Retreat Photos

Retreat photos are now available here
Posted On 12/8/2008 - Archived On 2/7/2009

Mt. Sinai Scholar in our Midst

Congratulations to Dr. John Feng who has just been named as a Mt. Sinai Scholar! This is a very competitive award provided by the Mt. Sinai Foundation for newly recruited basic science faculty.
Posted On 10/2/2008 - Archived On 11/20/2008

Spotlight Series Prize Award

Congratulations to Dr. Ruth Keri who has been awarded the 2008 Mather Spotlight Series Prize for Women's Scholarship. Dr. Keri was among eight women scholars who received their awards from President Snyder at a special luncheon in their honor on September 26th. Dr. Keri is an expert in the field of molecular endocrinology and uses genetically manipulated animal models to study molecular mechanisms of reproductive endocrinology.
Posted On 9/26/2008 - Archived On 10/30/2008

K08 Awarded to Maeda!

Congratulations to Dr. Akiko Maeda (Palczewski lab) who has just been awarded a K08 award to fund her research for the next 5 years!!! Dr. Maeda is studying retinal degenerative diseases and working to develop models that will facilitate the evaluation of the safety and efficacy of drug candidates designed to combat retinal disease in humans.
Posted On 8/26/2008 - Archived On 11/25/2008

A new Ph.D.!

We wish Yan Qu the best.  She successfully defended her dissertation "Regulation of Multiple Membrane Trafficking Pathways Stimulated by P2X7 Receptor Activation in Inflammatory Macrophages."  She is leaving Dr. George Dubyak's lab to continue her research as a PostDoctoral Fellow.
Posted On 8/18/2008 - Archived On 9/17/2008

A Successful Dissertation!

Melissa Shelton had a well defended dissertation entitled "Glutaredoxin-Regulated Nuclear Factor-κβ (NFκβ) Signaling in Retinal Müller Glial Cells Treated with High Glucose, a Model of Diabetic Retinopahty." Melissa leaves with not only her PhD but many memories in the Department of Pharmacology!
Posted On 8/5/2008 - Archived On 9/4/2008

Off to bigger and better things...

Vivian Gama will be leaving our department after successfully defending her dissertation "Characterization and Regulation of the Anti-apoptotic Protein Ku70 - Implications for Bax-mediated Apoptosis." Her contributions to the department have been immeasurable and we wish her the best in her scientific career. 
Posted On 8/4/2008 - Archived On 9/3/2008

Good Luck!

Hui Wang successfully defeated his defense entitled "The roles of a LIM domain protein, Hic-5 / ARA55, in TGF-β signaling in prostate cancer cells."  We wish him the best as he continues his research in Biostatistics!

Posted On 7/31/2008 - Archived On 8/30/2008

SURP Comes to an End...

At the final poster presentations, 8 summer researchers presented their findings and results.  The students all did a great job and hopefully learned a lot over the last 10 weeks!

Posted On 7/30/2008 - Archived On 8/29/2008

Nature Neuroscience

Don't miss Dr. John Feng's recent article in Nature Neuroscience!

Nature Neuroscience Article

Posted On 7/25/2008 - Archived On 8/24/2008

In the Plain Dealer!

Dr. Kris Palczewski was recently featured in the Cleveland Plain Dealer.  The article is titled "Case Western Reserve's new medical researchers pump millions into Northeast Ohio economy" More Info

Posted On 7/22/2008 - Archived On 8/21/2008

Congratulations!

Smitha Sripathy successfully defended her dissertation, "Mechanisms of Transcriptional Regulation: Gene Repression by KRAB Zinc Finger Proteins and Gene Induction by Estrogen Receptor Beta" on July 14, 2008. We wish her the best in her future Postdoctoral career!
Posted On 7/16/2008 - Archived On 8/18/2008

Dr. Youwei Zhang Joins Pharmacology Faculty

The Department of Pharmacology is pleased to welcome Dr. Youwei Zhang to its faculty! Dr. Zhang is an expert in the field of cell cycle and has published numerous articles on replication checkpoint. Read more about Dr. Zhang and his research.

Posted On 7/15/2008 - Archived On 2/15/2009

Keri Lab Challenge

It was the best of times, it was the worst of times and in the end, the Keri Lab dominated their challenge…... Until next time, that is!

Posted On 6/12/2008 - Archived On 7/12/2008

von Lintig Lab Arrives

The Department of Pharmacology is pleased to welcome Dr. Johannes von Lintig and his lab members, Sylvia Hoff (Research Scholar) and Susanne Hessel (Postdoctoral Fellow)!

Posted On 5/7/2008 - Archived On 7/6/2008

Park Joins Opthalmology Faculty

Congratulations to Dr. Paul Park, a postdoctoral fellow in the Palczewski lab, who has accepted a faculty position in the Department of Opthalmology and Visual Sciences at Case. Paul will begin his tenure track position as an assistant professor July 1 and will continue to pursue his research interests aimed at understanding the signaling mechanism in phototransduction and other G protein-coupled receptor-mediated systems. We wish Paul the best of luck as he pursues his independent career!

Posted On 5/5/2008 - Archived On 6/4/2008

Deans Scientific Research Symposium, 4/30/08

Sponsored by
Dean Pamela B. Davis, M.D., Ph.D.
and the Department of Pharmacology

Download the Symposium Program

Video from Symposium

Posted On 4/24/2008 - Archived On 5/24/2008

Research ShowCASE winners!

Congratulations to our graduate students Vivian Gama and Marjorie Montanez-Wiscovich whose posters were recognized at the 2008 Research ShowCASE.  Vivian received one of only ten Grand Prizes awarded for her poster entitled "Hdm2 is a ubiquitin ligase for the anti-apoptotic protein Ku70",  and Marjorie received an honorable mention for her poster entitled "LMO4 is essential for ErbB2-mediated breast cancer cell proliferation and cell cycle progression."  

Posted On 4/22/2008 - Archived On 5/22/2008

Pharmacology Wins First Place!

A group of students, post-docs, and faculty dominated the field of 16 teams at the First Annual Philanthropy Dodgeball Tournament held on April 13th. The tournament was held to support the activities of the American Red Cross. By going undefeated, Team Pharmacology lived up to their creed -If you ain`t first, you`re last!

Posted On 4/17/2008 - Archived On 5/17/2008

Alumni receives Award

Tehnaz Parakh, a recent MTTP graduate currently in her Med School rotations, has been nominated and will receive, the Noether Memorial Fund Award for excellence in theraputics during the Graduation Award Ceremony.  

Congratulations Tehnaz!'

Posted On 4/8/2008 - Archived On 5/8/2008

NIH funding!

Tonibelle Gatbonton was just awarded a Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows.  Good job, Tonibelle!

Posted On 3/21/2008 - Archived On 4/20/2008

Well defended!

Congratulations to Tim Miller for successfully defending his disertation "FXYD5 modulates Na, K-ATPase activity and is increased in cystic fibrosis airway epithelia."  Tim Miller is leaving Pam Davis's lab and is going to continue his research in the Cleveland area.  We wish him the best!
Posted On 3/21/2008 - Archived On 4/20/2008

ASPET 's recent elections:

  We would like to congratulate Dr. Amy Wilson-Delfosse on her recently elected position as the Secretary-Treasurer-elect of the ASPET Division for Pharmacology Education. This is an honor for Dr. Wilson-Delfosse and is an excellent example of her engagement and dedication to education in the pharmacological sciences!
Posted On 2/27/2008 - Archived On 3/28/2008

Congratulations!

  Krisztina Papp-Wallace successfully defended her dissertation entitled "Studies on the Virulence Properties and Regulation of the CorA Magnesium Channel" on Wednesday, February 20th.  She's now moving from Dr. Mike Maguire's lab to Dr. Robert Bonomo's lab for her Postdoctoral position. 
Posted On 2/27/2008 - Archived On 3/28/2008

Alpha Omega Alpha Honor Medical Society

Congratulations to Tehnaz Parakh (Ph.D. Pharmacology 2006) who has been elected to the Alpha Omega Alpha Honor Medical Society. Election into the society is highly competitive and is reserved for the most accomplished of medical students.

Posted On 1/4/2008 - Archived On 2/3/2008

Holiday Party

Pictures from the holiday party at Shooters on the Water.

Posted On 12/18/2007 - Archived On 1/20/2008

Department of Pharmacology on the Move!

The Department of Pharmacology celebrates the opening of its newly renovated space and also its entry into the top 10 pharmacology departments in the nation!

Posted On 11/30/2007 - Archived On 3/30/2008

Congratulations!

 

Payal Gandhi successfully defended her dissertation entitled "Characterization of the Parkinson's disease assocated protein, leucine-rich repeat kinase 2 (LRRK2), as a Ras-related GTPase" on 11/16.  We wish Payal the best in her continued research!

Posted On 11/19/2007 - Archived On 12/19/2007

Retreat

Pharmacology Retreat pictures are now available on-line here

Posted On 11/13/2007 - Archived On 12/13/2007

Dr. Andreas Engel

 

The Departmenty of Pharmacology welcomes Dr. Andreas Engel to come speak on the topic of "Electron and Atomic Force Microscopes: Tools for cellular Nanoanalytics" in BRB105 on Thursday, November 15th.

Posted On 11/7/2007 - Archived On 11/16/2007

Dr. Johannes von Lintig joins Pharmacology

 

Dr. von Lintig will join the faculty at Case in spring 2008 as an Assistant Professor of Pharmacology. Read more about Dr. Lintig and his research.

Posted On 11/5/2007 - Archived On 1/31/2008

Dr. John Feng joins Pharmacology

Dr. Feng will join the faculty at Case in the fall of 2007 as Assistant Professor of Pharmacology. Read more about Dr. Feng and his research.

Posted On 10/15/2007 - Archived On 11/14/2007

Palczewski Honored by National Eye Institute

 

Krzysztof Palczewski, Ph.D., John H. Hord Professor and Chair of the Department of Pharmacology has been honored by the National Eye Institute of the National Institutes of Health by being selected as the 2007 Sayer Vision Research Lecture and Award winner.

Posted On 9/29/2007 - Archived On 10/29/2007

Nathan S. Greenfield Family Lecture

 

The Department of Pharmacology is pleased to announce this year's Nathan S. Greenfield Family Lecture. Dr. Dino Moras, Director of Research, CNRS, Strasbourg, France, and Head, Structural Biology Laboratory, Illkirch,France will be speaking on " Nuclear Hormone Receptors: Structural basis for two functional features" on September 25, at 4pm in the Wolstein Auditorium.

 

Posted On 9/14/2007 - Archived On 10/14/2007

Papp-Wallace on Cover!

Congratulations to Krisztina Papp-Wallace of the Maguire laboratory for having her recent review featured on the cover of Molecular Membrane Biology!!!
Read Krisztina's manuscript.

Posted On 9/7/2007 - Archived On 10/7/2007

ACS Fellowship:

Congratulations to Tonibelle Gatbonton who received a Joseph S. Silber Fellowship from the American Cancer Society!
Posted On 8/27/2007 - Archived On 9/26/2007

Dr. Chris Dealwis joins Pharmacology

Dr. Dealwis will join the faculty at Case in the fall of 2007 as Associate Professor of Pharmacology. Read more about Dr. Dealwis and his research.

Posted On 8/6/2007 - Archived On 9/5/2007

Annual Pharmacology Research Symposium

The 2007 annual Department of Pharmacology Retreat will be held from October 25 to 26 at the Lodge at Geneva State Park. Click here for more information and to register.

Posted On 8/6/2007 - Archived On 9/26/2007

Dr. Shasta Sabo joins Pharmacology

Dr. Sabo will join the faculty at Case in the fall of 2007 as Assistant Professor of Pharmacology. Read more about Dr. Sabo and her research.

Posted On 8/5/2007 - Archived On 8/30/2007

Montano Lab in the news

The Department of Pharmacology was a feature story for WKYC's news story, "Case Medical School encouraging young researchers and future doctors".  The Montano Lab participates in a program that selects local students with an interest in research.  Click here for video

Posted On 8/2/2007 - Archived On 9/1/2007

Pharmacology Backup System is here!

Pharmacology Backup System is launched. Department Members who are in need of a backup tool can register to use this service.
Posted On 7/31/2007 - Archived On 12/30/2007

He did it!

Congratulations to Reggie Gray who successfully defended his dissertation entitled "Regulation of Interferon ?? Induction and Dendritic Cell Function by CpG Oligodeoxynucleotides".  Reggie continues and will be heading off to Virginia Tech to complete his MD.  We wish Reggie all the best in his continued research!

Posted On 7/20/2007 - Archived On 8/19/2007

Well defended!

Congratulations go to Jonathan Mosley who successfully defended
his dissertation entitled "The analysis and utilization of global gene expression data for the study and treatment of breast cancer."
Jonathan defended on June 27^th and will now continue finishing his MD/Ph.D. in the School of Medicine.

Posted On 6/28/2007 - Archived On 8/15/2007

Yee-Hsee Defends

Yee-Hsee Hsieh successfully defended his disertation "BRAINSTEM GABAA RECEPTOR SHAPES THE RESPONSE AND ADAPTATION TO HYPOXIA."  Congrats Yee-Hsee!

Posted On 6/28/2007 - Archived On 8/15/2007

Dr. Jodi is an Ironman!

   Jodi Thomson, a student in the Medical Scientist Training Program and recent graduate of the Department of Pharmacology, competed in the Ironman Challenge  in Coeur d'Alene, Idaho. As part of the challenge, Thomson was raising money for lymphoma. Read more about the race.  Judi finished in 12:27.  Good job, Jodi!
Posted On 6/22/2007 - Archived On 8/15/2007

Park Received Pathway to Independence Award

Congratulations to Paul Park who has received an NIH Pathway to Independence Award for his research proposal entitled,  "Towards a structural and temporal understanding of phototransduction". Read  more...

Posted On 6/6/2007 - Archived On 7/6/2007

Pharmacology Graduate Students Win Big!

Congratulations to Pharmacology graduate students Payal Gandhi, Yan Qu and Yiping Rong who all won Poster Presentation Awards at this years Biomedical Graduate Student Symposium!

Posted On 5/23/2007 - Archived On 6/22/2007

The Yin and Yang of Retinoic Acid Signalling

Noa Noy and her lab published their recent work on how retinoic acid affects cell growth by activating two different nuclear receptors. Read more...
 
 

Posted On 5/22/2007 - Archived On 6/21/2007

A Successful Defense!

Jodi Thomson delivered her final dissertation, entitled "Overcoming Inhibitor Resistance in the SHV Beta-Lactamase" on Friday, May 18th. Jodi is an MSTP student who worked in Dr. Robert Bonomo's lab. Great job, Jodi!

Posted On 5/21/2007 - Archived On 6/20/2007

Good News!

Yan Qu won the "Graduate Student Best Abstract Award" of the American Society for Pharmacology and Experimental Therapeutics (ASPET) in Experimental Biology 2007 conference held in Washington DC from Apr. 28 to May 3, 2007. Good Job, Yan!

Posted On 5/8/2007 - Archived On 6/7/2007

2007 A.L. Chilton Lecture

Krzysztof Palczewski, Ph.D., John H. Hord Professor and Chair was the 2007 A.L. Chilton Lecturer in the Department of Biochemistry at UT Southwestern Medical Center. Dr. Palczewski is pictured in the company of Nobel laureates Drs. Johann Deisenhofer, Michael Brown, Josepha Goldstein and Alfred Gilman (left to right).

Posted On 5/7/2007 - Archived On 6/6/2007

Scientific Research Symposium

Sponsored by
Interim Dean, Pamela B. Davis, M.D., Ph.D.
and the Department of Pharmacology
Friday, May 11, 2007
9:00am-5:00pm
Wolstein Auditorium
2103 Cornell Road
Download the Symposium Program

Links for the live webcast for Friday talks

Posted On 5/7/2007 - Archived On 5/11/2007

Research Showcase Award Winners!

Congratulations to pharmacology graduate student, Yiping Rong (1st place - Interaction of Bc1 - 2 with the Activation Coupling Domain of IP3 Receptor) and Tim Miller (honorable mention - FXYD5 is upregulated) in cystic fibrosis airway epithelia and modulates wound healing) for their award winning poster presentations at the 2007 Research ShowCASE.

Posted On 5/4/2007 - Archived On 5/11/2007

Off to LA!

Rod Nibbe and Jonathan Mosley both had abstracts accepted by the American Association for Cancer Research (AACR). They will be presenting their work at the annual conference in Los Angeles this April. Great Job, Rod and Jonathan!
Posted On 3/16/2007 - Archived On 4/15/2007

Congratulations to recent student JBC authors

Melissa Shelton of the Mieyal laboratory is publishing her work entitled, “Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Muller cells: Model of diabetic retinopathy” in the Journal of Biological Chemisty.

Tara Ellison of the MacDonald laboratory is publishing her work entitled, “Evidence for 1,25(OH)2D3-independent transactivation by VDR: Uncoupling the receptor and ligand in Keratinocytes” in the Journal of Biological Chemistry.

Posted On 3/13/2007 - Archived On 5/12/2007

Gallogly Receives NRSA Grant:

Congratulations to Molly Gallogly of the Mieyal laboratory who has received an NRSA F30 pre-doctoral grant for MD/PhD students for her work on the "Role of GRx in the regulation of calcium homeostasis in the aging heart."
Posted On 3/13/2007 - Archived On 5/12/2007

Graduate Student Efforts Feed the Hungry:

Appreciation goes out to the graduate students of the Department of Pharmacology who collected 108 food items and $164 during the CWRU Graduate Student Senate (GSS) annual Food Drive. This is the third consecutive year that the Department of Pharmacology has earned the distinction of being the most generous during this annual event and has been honored with a financial prize from the GSS. At the suggestion of the students, the department fully supported the additional donation of this prize to the Cleveland Food Bank. The Cleveland Food Bank is one of the largest charities in Northern Ohio and potentially the largest metropolitan foodbank in the country. The Cleveland Foodbank supplies food for use in local soup kitchens, shelters and food pantries, child-care centers, group homes and programs for the elderly. For every $1 donation, the Foodbank is able to distribute enough food to prepare four nutritious meals for the hungry in the Cleveland area. The financial contributions received from the Department of Pharmacology alone will supply over 1800 meals.
Posted On 3/7/2007 - Archived On 5/7/2007

Annual Scholarship in Teaching Award:

Amy Wilson-Delfosse was awarded a 2006 Scholarship in Teaching Award that recognizes medical school faculty for making distinct contributions to education and having an impact on the advancement of medical instruction. The title of the project recognized was "Progressive Assessment in the Fundamentals of Therapeutic Agents Committee".
Posted On 1/3/2007 - Archived On 3/2/2007

Congratulations!

Nicole White successfully defended her disertation entitled "Inherent flaw of cholesterol processing in cultured and in vivo models of cystic fibrosis" on November 16th.
Posted On 1/3/2007 - Archived On 3/2/2007

Congratulations to David Lodowski, Ph.D of the Palczewski lab upon the publication of his recent work "Structure of the Photoactivated State of Rhodopsin" in PNAS.

Posted On 12/6/2006 - Archived On 3/8/2007

Montano Honored by Ohio Cancer Research Associates:

Congratulations to Dr. Monica Montano who was recently recognized by the Ohio Cancer Research Associates for her achievements in the field of cancer research. Dr. Montano's research focuses on estrogen receptor-selective coactivators in breast cancer cells.
Posted On 11/27/2006 - Archived On 1/31/2007

Keri Makes Front Page!

Don't miss the November 27th edition of the Cleveland Plain Dealer to read about Dr. Ruth Keri's research, lab and life in science.
Posted On 11/27/2006 - Archived On 2/21/2007

Nathan S. Greenfield Family Lecture

The Department of Pharmacology welcomed Dr. Robert J. Lefkowitz for the annual Nathan S. Greenfield Family Lecture. View Dr. Lefkowitz's seminar "Seven Transmembrane Receptors".

Posted On 10/25/2006 - Archived On 12/25/2006

Kiser Receives Loan Repayment Award:

Congratulations to Philip Kiser who received an award from the Pediatric Loan Repayment Program administered through the NIH.
Posted On 10/24/2006 - Archived On 11/23/2006

Young Scientist Award:

Congratulations to Yan Qu who won the 1st place award in the Van Arman Young Scientist Award Competition at the 14th international meeting of the Inflammatory Research Association held in Cambridge, Maryland.
Posted On 10/20/2006 - Archived On 11/19/2006

Retreat 2006 - Keynote Speaker

The Department of Pharmacology welcomed Dr. Tony Adamis ((osi) eyetech) as our keynote speaker for the 2006 Departmental Research Symposium held at Squire Vallevue Farm.
Posted On 10/19/2006 - Archived On 11/16/2006

Wilson-Delfosse Wins Medical Education Award:

Congratulations to Amy Wilson-Delfosse for winning the Outstanding Presentation Award at the 2006 meeting of the International Association of Medical Science Educators (IAMSE) for her work entitled, "Team-based Learning: An Effective Method for Teaching Pharmacology". Amy's was one of approximately 90 presentations given at the annual meeting.
Posted On 10/17/2006 - Archived On 12/1/2006

Retreat 2006 Awards!

Congratulations to Vivian Gama who received the Student of the Year award. Elizabeth Sabens received the Greenfield Travel Award and Payal Gandhi received the best Retreat Presentation Award sponsored by Lerner Research Institute.

Posted On 10/11/2006 - Archived On 11/12/2006

Renovations Begin!

The Chair of the Department of Pharmacology, Kris Palczewski, Vice Chair John Mieyal, and Michael Maguire, the architectural liaison for the Department, in the official wall breaking, all of whom enthusiastically wielded a sledgehammer to begin the demolition of the current third floor laboratories, marking the exciting beginning of the first phase of construction of completely new laboratories for the Department. Read More about the renovations
Posted On 8/15/2006 - Archived On 10/25/2006

Noa Noy Joins Department of Pharmacology

Dr.Noa Noy, well-known nuclear receptor expert, is joining the Case faculty as professor in the Department of Pharmacology. Read full story...

Posted On 6/13/2006 - Archived On 10/1/2006

Registration now open

The Department of Pharmacology Retreat registration and abstract submission is now open! Click here for information and registration.

 The registration and abstract submission closes on October 6^th.

Posted On 9/2/2008 - Archived On 10/6/2008

The Department of Pharmacology (Case School of Medicine) in collaboration with the Department of Psychiatry (University Hospitals of Cleveland) seeks to identify a faculty member(s) to direct the development of a highly collaborative program of Neuropharmacology within the Department of Pharmacology. More details and application instructions are available here.
Posted On 4/1/2006 - Archived On 4/30/2006

Keri Scores!

Congratulations to Ruth Keri for her 6.6 percentile score on her NCI competitive renewal “Regulation of erbB2/Neu-induced mammary gland cancer”!
Posted On 10/17/2006 - Archived On 10/25/2006

Maguire receives RO1:

Mike Maguire has received a new 4 year R01 from NIGMS for his project entitled "Magnesium Homeostasis in Microorganisms". The Maguire lab has also been very prolific over the last couple months. Click here for a list of their most recent publications.
Posted On 7/25/2006 - Archived On 8/24/2006

Keri Receives Komen Award:

Ruth Keri has received a Susan G. Komen Breast Cancer Foundation Grant for $250,000 over two years for her proposal titled "Evaluating the role of GKLF/KLF4 in mammary gland development and carcinogenesis". Click here to learn more about the Komen Foundation and its goal to eradicate breast cancer.
Posted On 7/24/2006 - Archived On 8/23/2006

Chen and Wilson-Delfosse Receive NPF Mega Award:

Congratulations to Shu Chen and Amy Wilson-Delfosse whose collaborative proposal entitled “Uncovering the pathogenic role of LRRK2 in Parkinson disease using molecular and chemical genetic approaches” has received a National Parkinson Foundation Mega Award.
Posted On 7/24/2006 - Archived On 8/23/2006

Keri in the News:

Orange Country Register Reporter, Gary Robbins (aka Sciencedude) interviews Ruth Keri on genes and breast cancer. Hear the audio blog.
Posted On 5/30/2006 - Archived On 6/30/2006

Congratulations to Dr. Michael Maguireon the publication of the crystal structure of CorA Mg²⁺ channel in the April 6 edition of Nature.
Read more

Posted On 4/13/2006 - Archived On 6/2/2006

Congratulations

to Tara Ellison, Nicole White and Jonathan Mosley for being selected to present their research at the NIH National Graduate Student Research Festival held this October at the NIH. All expenses are paid, and up to 250 students are involved.
Posted On 8/28/2006 - Archived On 9/27/2006

At the Gordon Research Conference, "Drug Carriers in Medicine and Biology", the Chair's award for the best student poster presentation was presented to graduate student, Jose Gomez. Good job, Jose!
Posted On 8/28/2006 - Archived On 9/27/2006

Congratulations to Gina Bernardo who successfully competed for a Pre-doctoral fellowship from the Department of Defense Breast Cancer Research Program with her proposal entitled "Functional interaction between Her2/ErbB2 and Met receptor signaling in breast cancer." Gina is completing her thesis work in the Keri laboratory. For more information on the DODBCRP please follow This Link .
Posted On 8/22/2006 - Archived On 9/21/2006

Yan Qu has been selected as a finalist for the 2006 C. Gordon Van Arman Scholarship Award competition. Based on a submitted paper, she will compete at the International IRA Conference in October. Good luck Yan!
Posted On 7/14/2006 - Archived On 8/13/2006

Please congratulate Krisztina Papp-Wallace. She has received a $500 travel award from the American Society for Microbiology to attend the "2nd International Conference on Salmonella" to he held in September in Victoria, British Columbia.
Posted On 7/14/2006 - Archived On 8/13/2006

Congratulations to Jodi Thomson who in one week published two articles in the June edition of JBC. Her articles can be found at Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244: Understanding unique properties of inhibitor resistance and Structural and computational characterization of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein(BLIP) interface
Posted On 6/30/2006 - Archived On 7/30/2006

Prelim I Success!

Congratulations to Linnea Patt and Elizabeth Sabens who recently withstood the rigors of the two-part Prelim I examination and passed.
Posted On 6/27/2006 - Archived On 7/27/2006

Congratulations to Mike Davis who successfully defended his dissertation entitled "“Investigations into the Generation and Regulation of Pro- Apoptotic Ca²+ Signals in T Cells.”
Posted On 6/8/2006 - Archived On 7/8/2006

Congratulations go to Marjorie Montanez-Wiscovich who has received an NRSA pre-doctoral training award from the National Cancer Institute.
Posted On 6/2/2006 - Archived On 7/2/2006

Congratulations go to Jose Gomez who recently received an American Heart Association Predoctoral Fellowship with an outstanding score.
Posted On 5/10/2006 - Archived On 6/10/2006

Pharmacology Students Win Biomedical Graduate Student Symposium Competitions!

Marjorie Montanez-Wiscovich received the President's award for the best oral presentation at the Case Biomedical Graduate Student Symposium ("LMO4 is Necessary for Maintenance of Cyclin D1 Expression in Breast Cancer Cells"). Melissa Bentle ("Altered Cellular Metabolism and Repair Through Poly(ADP-ribose) Polymerase-1 Hyperactivation to Enhance Cancer Therapy") and Vivian Gama ("Poly-Glutamine Disease Induces Bax-Mediated Cell Death through Ku70 Acetylation") were recognized as winners in the poster presentation session. Congratulations to these students and all students who took part in this event.
Posted On 5/8/2006 - Archived On 5/15/2006

Congratulations to recent graduate Melissa Landis whose manuscript entitled, "Sustained trophism of the mammary gland is sufficient to accelerate and synchronize development of ErbB2/Neu-induced tumors" has been published in Oncogene. Melissa is now a post-doctoral fellow in Jeff Rosen's lab in the Molecular and Cellular Biology Department at Baylor College of Medicine. Her work focuses on identifying mammary cancer stem cells.
Posted On 5/2/2006 - Archived On 6/2/2006

Congratulations to Vivian Gama who won the University Hospitals of Cleveland Award for the presentation of her poster, "Polyglutamine disease induces Bax-mediated cell death through Ku70 acetylation" at the Research ShowCASE.
Posted On 5/2/2006 - Archived On 6/2/2006

Marjorie Montanez-Wiscovich has received a travel award from the Endocrine Society to attend their 88th annual meeting in Boston in June, 2006. The title of her oral presentation is "LMO4 is necessary for maintenance of Cyclin D1 expression in breast cancer cells".
Posted On 5/2/2006 - Archived On 6/2/2006

Congratulations go to Yu-Ting Chou who successfully defended his dissertation entitled “Cited2, an autoregulated transcriptional modulator, in TGF- b signaling” on May 3, 2006. Yu-Ting plans to start interviewing for PostDoc positions this summer.
Posted On 5/2/2006 - Archived On 6/2/2006

Congratulations go to John Poirier who won first place in the Michelson-Morley Biology Research Competition for Case Undergraduates with his presentation entitled "Rapamycin inhibits primary tumor growth in a transgenic model of HER2-dependent breast cancer." He was also awarded second place for his research paper with the same title that was submitted to the SOURCE Undergraduate Research Symposium in the category of Natural Sciences. John is completing his undergraduate research in Dr. Ruth Keri's laboratory and will join the Ph.D. training program in Cellular and Molecular Medicine at Johns Hopkins University in the fall. For more information about SOURCE, please see the following link: http://www.case.edu/provost/source/index.html.
Posted On 5/2/2006 - Archived On 6/2/2006

Graduate Student Symposium

Don't miss the 29th Annual Biomedical Graduate Student Symposium to be held on May 5, 2006. Representing the Department of Pharmacology are poster presenters: Smitha P. Sripathy, Jennifer L. Yori, Jonathan Mosley, Payal N. Gandhi, Reginald C. Gray, Vivian Gama, Tara Ellison,Melissa D. Shelton, Jose A. Gomez, Andrea S. Moomaw, Jodi M. Thomson, Melissa S. Bentle and Marjorie Montanez-Wiscovich with an oral presentation. Please see http://filer.case.edu/org/bgss/schedule.html for complete details.
Posted On 5/2/2006 - Archived On 5/6/2006

New Students:

The Department of Pharmacology would like to welcome four new students to the Molecular Therapeutics Training Program from the Biomedical Sciences Training Program . Reema Wahdon and Jennifer Leising will be joining Dr. Danielpour's lab, Gina Bernardo will be joining Dr. Keri's lab, and Xiaoming Zhou will be joining Dr. Palczewski's lab.
Posted On 4/13/2006 - Archived On 5/1/2006

Ndiya Ogba received a highly competitive Department of Defense Fellowship. Ndiya was recognized for her past two years of research on the estrogen receptor in breast cancer. This is a three year fellowship that will support her continued work in this area of research.
Posted On 4/13/2006 - Archived On 5/1/2006

Jodi Thomson received a travel fellowship from the American Society for Biochemistry and Molecular Biology (ASBMB) to attend the 2006 Experimental Biology conference in San Francisco April 1-5.
Posted On 4/13/2006 - Archived On 5/1/2006

Philip Kiser was recently appointed to the Visual Sciences Training Grant. This is a T32 training grant awarded to Case from the Department of Health and Human Services. Awards are appointed based on a competitive application process to students doing vision-related dissertation research.
Posted On 4/13/2006 - Archived On 5/1/2006

Congratulations toVivien Gama whose publication "Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis" appears in the February 15 edition of Experimental Cell Research (Gama V, Yoshida T, Gomez JA, Basile DP, Mayo LD, Haas AL, Matsuyama S.; Exp Cell Res. 2006 Feb 15;312(4):488-99).
Posted On 4/13/2006 - Archived On 5/1/2006

Congratulations to recent graduate Melissa Landis whose manuscript entitled, "Sustained trophism of the mammary gland is sufficient to accelerate and synchronize development of ErbB2/Neu-induced tumors" has been published in Oncogene. Melissa is now a post-doctoral fellow in Jeff Rosen's lab in the Molecular and Cellular Biology Department at Baylor College of Medicine. Her work focuses on identifying mammary cancer stem cells.
Posted On 4/13/2006 - Archived On 5/1/2006

Please congratulate Krisztina Papp-Wallace. Her review for Volume 60 of Annual Reviews of Microbiology 2006, "Manganese Transport and the Role of Manganese in Virulence", has been accepted by the reviewers and editors with NO recommended revisions.
Posted On 4/13/2006 - Archived On 6/1/2006

The Department of Pharmacology would like to congratulate Samantha Cicero on successfully defending her dissertation entitled "The Roles of Cdk5 in Neuronal Development and Neurodegeneration". Samantha will continue her research by investigating the role of retinoblastoma (Rb) in cell cycle exit and neuronal differentiation as a Post-Doctoral Fellow in Dr. Michael Dyer's laboratory at St. Jude Children's Research Hospital.
Posted On 3/13/2006 - Archived On 5/1/2006

Congratulations to Paul Park who has received a three year postdoctoral fellowship from The Foundation Fighting Blindness!
Posted On 5/18/2006 - Archived On 6/16/2006

Congratulations to Emhonta (Monty) Johnson who was appointed to the Oncological Sciences Training Grant.

Posted On 4/13/2006 - Archived On 6/2/2006

Department of Pharmacology Alumni, click here to take our Alumni Survey.
Posted On 5/2/2006 - Archived On 7/31/2006

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